Targeting Nuclear Mechanics Mitigates the Fibroblast Invasiveness in Pathological Dermal Scars Induced by Matrix Stiffening

Targeting Nuclear Mechanics Mitigates the Fibroblast Invasiveness in Pathological Dermal Scars Induced by Matrix Stiffening

Abstract Pathological dermal scars such as keloids present significant clinical challenges lacking effective treatment options. Given the distinctive feature of highly stiffened scar tissues, deciphering how matrix mechanics regulate pathological progression can inform new therapeutic strategies. He...

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Bibliographic Details
Main Authors: Xiangting Fu, Ali Taghizadeh, Mohsen Taghizadeh, Cheng Ji Li, Nam Kyu Lim, Jung‐Hwan Lee, Hye Sung Kim, Hae‐Won Kim
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Advanced Science
Subjects:
cell migration
cellular mechanosensing
matrix stiffness
nuclear lamin
pathological dermal scar
Online Access:https://doi.org/10.1002/advs.202308253

Internet

https://doi.org/10.1002/advs.202308253

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