Conditioned medium derived from bovine umbilical mesenchymal stem cells as an alternative source of cell-free therapy
Umbilical cord blood (UCB) cells are an important source of mesenchymal stem cells (MSCs). It is known that the umbilical cord is rich in hematopoietic stem cells, which influenced research on ontogeny and transplantation (allogeneic transplantation). In recent years, stem cell research has emerged...
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| Format: | Article |
| Language: | English |
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Veterinary World
2021-10-01
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| Series: | Veterinary World |
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| Online Access: | http://www.veterinaryworld.org/Vol.14/October-2021/2.pdf |
| _version_ | 1818739800472027136 |
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| author | Dwi Liliek Kusindarta Hevi Wihadmadyatami |
| author_facet | Dwi Liliek Kusindarta Hevi Wihadmadyatami |
| author_sort | Dwi Liliek Kusindarta |
| collection | DOAJ |
| description | Umbilical cord blood (UCB) cells are an important source of mesenchymal stem cells (MSCs). It is known that the umbilical cord is rich in hematopoietic stem cells, which influenced research on ontogeny and transplantation (allogeneic transplantation). In recent years, stem cell research has emerged as an area of major interest due to its prospective applications in various aspects of both human and veterinary medicine. Moreover, it is known that the application of MSCs has several weaknesses. The use of these cells has limitations in terms of tumorigenesis effect, delivery, safety, and variability of therapeutic response, which led to the use of secretomes as an alternative to cell-free therapy. The main obstacle in its use is the availability of human UCB as an origin of MSCs and MSCs' secretomes, which are often difficult to obtain. Ethical issues regarding the use of stem cells based on human origin are another challenge, so an alternative is needed. Several studies have demonstrated that MSCs obtained from bovine umbilical cords have the same properties and express the same surface markers as MSCs obtained from human umbilical cords. Therefore, secretomes from MSCs derived from domestic animals (bovine) can possibly be used in human and veterinary medicine. This finding would contribute significantly to improve cell-free therapy. At present, the use of UCB MSCs derived from domestic animals, especially bovines, is very restricted, and only limited data about bovine UCB are available. Therefore, the aim of this review was to provide an updated overview of cell-free therapy and discuss the new possibilities introduced by the generation of this therapy derived from bovine umbilical MSCs as a promising tool in developing modern and efficient treatment strategies. |
| first_indexed | 2024-12-18T01:30:35Z |
| format | Article |
| id | doaj.art-4f0a2ba79b8b496d8fb9fc554a123ec3 |
| institution | Directory Open Access Journal |
| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-12-18T01:30:35Z |
| publishDate | 2021-10-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj.art-4f0a2ba79b8b496d8fb9fc554a123ec32022-12-21T21:25:37ZengVeterinary WorldVeterinary World0972-89882231-09162021-10-0114102588259510.14202/vetworld.2021.2588-2595Conditioned medium derived from bovine umbilical mesenchymal stem cells as an alternative source of cell-free therapyDwi Liliek Kusindarta0https://orcid.org/0000-0002-3994-205XHevi Wihadmadyatami1https://orcid.org/0000-0002-0587-6226Department of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia.Department of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia.Umbilical cord blood (UCB) cells are an important source of mesenchymal stem cells (MSCs). It is known that the umbilical cord is rich in hematopoietic stem cells, which influenced research on ontogeny and transplantation (allogeneic transplantation). In recent years, stem cell research has emerged as an area of major interest due to its prospective applications in various aspects of both human and veterinary medicine. Moreover, it is known that the application of MSCs has several weaknesses. The use of these cells has limitations in terms of tumorigenesis effect, delivery, safety, and variability of therapeutic response, which led to the use of secretomes as an alternative to cell-free therapy. The main obstacle in its use is the availability of human UCB as an origin of MSCs and MSCs' secretomes, which are often difficult to obtain. Ethical issues regarding the use of stem cells based on human origin are another challenge, so an alternative is needed. Several studies have demonstrated that MSCs obtained from bovine umbilical cords have the same properties and express the same surface markers as MSCs obtained from human umbilical cords. Therefore, secretomes from MSCs derived from domestic animals (bovine) can possibly be used in human and veterinary medicine. This finding would contribute significantly to improve cell-free therapy. At present, the use of UCB MSCs derived from domestic animals, especially bovines, is very restricted, and only limited data about bovine UCB are available. Therefore, the aim of this review was to provide an updated overview of cell-free therapy and discuss the new possibilities introduced by the generation of this therapy derived from bovine umbilical MSCs as a promising tool in developing modern and efficient treatment strategies.http://www.veterinaryworld.org/Vol.14/October-2021/2.pdfbovine umbilical cord bloodcell-free therapymesenchymal stem cellssecretome |
| spellingShingle | Dwi Liliek Kusindarta Hevi Wihadmadyatami Conditioned medium derived from bovine umbilical mesenchymal stem cells as an alternative source of cell-free therapy Veterinary World bovine umbilical cord blood cell-free therapy mesenchymal stem cells secretome |
| title | Conditioned medium derived from bovine umbilical mesenchymal stem cells as an alternative source of cell-free therapy |
| title_full | Conditioned medium derived from bovine umbilical mesenchymal stem cells as an alternative source of cell-free therapy |
| title_fullStr | Conditioned medium derived from bovine umbilical mesenchymal stem cells as an alternative source of cell-free therapy |
| title_full_unstemmed | Conditioned medium derived from bovine umbilical mesenchymal stem cells as an alternative source of cell-free therapy |
| title_short | Conditioned medium derived from bovine umbilical mesenchymal stem cells as an alternative source of cell-free therapy |
| title_sort | conditioned medium derived from bovine umbilical mesenchymal stem cells as an alternative source of cell free therapy |
| topic | bovine umbilical cord blood cell-free therapy mesenchymal stem cells secretome |
| url | http://www.veterinaryworld.org/Vol.14/October-2021/2.pdf |
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