Pathogenesis of Endometriosis: The Origin of Pain and Subfertility
Endometriosis (EM) and adenomyosis (AM) are common conditions with pain and infertility as the principal symptoms. The pathophysiology of pain in EM and AM comprises sensory and somatoform pain mechanisms. Over time, these may aggravate and lead to individual complex disease patterns if not diagnose...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/6/1381 |
| _version_ | 1797531506101452800 |
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| author | Teresa Mira Gruber Sylvia Mechsner |
| author_facet | Teresa Mira Gruber Sylvia Mechsner |
| author_sort | Teresa Mira Gruber |
| collection | DOAJ |
| description | Endometriosis (EM) and adenomyosis (AM) are common conditions with pain and infertility as the principal symptoms. The pathophysiology of pain in EM and AM comprises sensory and somatoform pain mechanisms. Over time, these may aggravate and lead to individual complex disease patterns if not diagnosed and treated. Despite the known facts, several years often pass between the onset of symptoms and diagnosis. Chronic pain disorders with changes on a neuronal level frequently arise and are linked to depressive disorders, with the process becoming a vicious cycle. Additionally, women with EM and AM suffer from sub- and infertility. Low fecundity rates are caused by anatomical changes in combination with behavioral changes in the sexual activity of women with chronic pain as well as local proinflammatory factors that not only decrease implantation rates but also promote early abortions. |
| first_indexed | 2024-03-10T10:44:46Z |
| format | Article |
| id | doaj.art-4f0a3d1a90e84244b4d37b0318909159 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T10:44:46Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4f0a3d1a90e84244b4d37b03189091592023-11-21T22:40:26ZengMDPI AGCells2073-44092021-06-01106138110.3390/cells10061381Pathogenesis of Endometriosis: The Origin of Pain and SubfertilityTeresa Mira Gruber0Sylvia Mechsner1Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Obstetrics, Augustenburger Platz 1, 13353 Berlin, GermanyCharité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Endometriosis Centre Charité, Department of Gynaecology, Augustenburger Platz 1, 13353 Berlin, GermanyEndometriosis (EM) and adenomyosis (AM) are common conditions with pain and infertility as the principal symptoms. The pathophysiology of pain in EM and AM comprises sensory and somatoform pain mechanisms. Over time, these may aggravate and lead to individual complex disease patterns if not diagnosed and treated. Despite the known facts, several years often pass between the onset of symptoms and diagnosis. Chronic pain disorders with changes on a neuronal level frequently arise and are linked to depressive disorders, with the process becoming a vicious cycle. Additionally, women with EM and AM suffer from sub- and infertility. Low fecundity rates are caused by anatomical changes in combination with behavioral changes in the sexual activity of women with chronic pain as well as local proinflammatory factors that not only decrease implantation rates but also promote early abortions.https://www.mdpi.com/2073-4409/10/6/1381endometriosisadenomyosispaininfertilitypathophysiologyinflammation |
| spellingShingle | Teresa Mira Gruber Sylvia Mechsner Pathogenesis of Endometriosis: The Origin of Pain and Subfertility Cells endometriosis adenomyosis pain infertility pathophysiology inflammation |
| title | Pathogenesis of Endometriosis: The Origin of Pain and Subfertility |
| title_full | Pathogenesis of Endometriosis: The Origin of Pain and Subfertility |
| title_fullStr | Pathogenesis of Endometriosis: The Origin of Pain and Subfertility |
| title_full_unstemmed | Pathogenesis of Endometriosis: The Origin of Pain and Subfertility |
| title_short | Pathogenesis of Endometriosis: The Origin of Pain and Subfertility |
| title_sort | pathogenesis of endometriosis the origin of pain and subfertility |
| topic | endometriosis adenomyosis pain infertility pathophysiology inflammation |
| url | https://www.mdpi.com/2073-4409/10/6/1381 |
| work_keys_str_mv | AT teresamiragruber pathogenesisofendometriosistheoriginofpainandsubfertility AT sylviamechsner pathogenesisofendometriosistheoriginofpainandsubfertility |