Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus <i>Cordyceps</i> with Its Nutraceutical and Therapeutic Potential
<i>Cordyceps</i> is a rare naturally occurring entomopathogenic fungus usually found at high altitudes on the Himalayan plateau and a well-known medicinal mushroom in traditional Chinese medicine. <i>Cordyceps</i> contains various bioactive components, out of which, cordycepi...
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MDPI AG
2020-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/12/2735 |
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| author | Syed Amir Ashraf Abd Elmoneim O. Elkhalifa Arif Jamal Siddiqui Mitesh Patel Amir Mahgoub Awadelkareem Mejdi Snoussi Mohammad Saquib Ashraf Mohd Adnan Sibte Hadi |
| author_facet | Syed Amir Ashraf Abd Elmoneim O. Elkhalifa Arif Jamal Siddiqui Mitesh Patel Amir Mahgoub Awadelkareem Mejdi Snoussi Mohammad Saquib Ashraf Mohd Adnan Sibte Hadi |
| author_sort | Syed Amir Ashraf |
| collection | DOAJ |
| description | <i>Cordyceps</i> is a rare naturally occurring entomopathogenic fungus usually found at high altitudes on the Himalayan plateau and a well-known medicinal mushroom in traditional Chinese medicine. <i>Cordyceps</i> contains various bioactive components, out of which, cordycepin is considered most vital, due to its utmost therapeutic as well as nutraceutical potential. Moreover, the structure similarity of cordycepin with adenosine makes it an important bioactive component, with difference of only hydroxyl group, lacking in the 3′ position of its ribose moiety. Cordycepin is known for various nutraceutical and therapeutic potential, such as anti-diabetic, anti-hyperlipidemia, anti-fungal, anti-inflammatory, immunomodulatory, antioxidant, anti-aging, anticancer, antiviral, hepato-protective, hypo-sexuality, cardiovascular diseases, antimalarial, anti-osteoporotic, anti-arthritic, cosmeceutical etc. which makes it a most valuable medicinal mushroom for helping in maintaining good health. In this review, effort has been made to bring altogether the possible wide range of cordycepin’s nutraceutical potential along with its pharmacological actions and possible mechanism. Additionally, it also summarizes the details of cordycepin based nutraceuticals predominantly available in the market with expected global value. Moreover, this review will attract the attention of food scientists, nutritionists, pharmaceutical and food industries to improve the use of bioactive molecule cordycepin for nutraceutical purposes with commercialization to aid and promote healthy lifestyle, wellness and wellbeing. |
| first_indexed | 2024-03-10T19:12:55Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:12:55Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4f0a4aef061c4e2985c3c4eb8e1104a72023-11-20T03:40:27ZengMDPI AGMolecules1420-30492020-06-012512273510.3390/molecules25122735Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus <i>Cordyceps</i> with Its Nutraceutical and Therapeutic PotentialSyed Amir Ashraf0Abd Elmoneim O. Elkhalifa1Arif Jamal Siddiqui2Mitesh Patel3Amir Mahgoub Awadelkareem4Mejdi Snoussi5Mohammad Saquib Ashraf6Mohd Adnan7Sibte Hadi8Department of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail PO Box 2440, Saudi ArabiaDepartment of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail PO Box 2440, Saudi ArabiaDepartment of Biology, College of Science, University of Hail, Hail PO Box 2440, Saudi ArabiaBapalal Vaidya Botanical Research Centre, Department of Biosciences, Veer Narmad South Gujarat University, Surat 395007, Gujarat, IndiaDepartment of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail PO Box 2440, Saudi ArabiaDepartment of Biology, College of Science, University of Hail, Hail PO Box 2440, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Science, Shaqra University, Al Dawadimi PO Box 17431, Saudi ArabiaDepartment of Biology, College of Science, University of Hail, Hail PO Box 2440, Saudi ArabiaSchool of Forensic and Applied Sciences, University of Central Lancashire, Preston PR1 2HE, UK<i>Cordyceps</i> is a rare naturally occurring entomopathogenic fungus usually found at high altitudes on the Himalayan plateau and a well-known medicinal mushroom in traditional Chinese medicine. <i>Cordyceps</i> contains various bioactive components, out of which, cordycepin is considered most vital, due to its utmost therapeutic as well as nutraceutical potential. Moreover, the structure similarity of cordycepin with adenosine makes it an important bioactive component, with difference of only hydroxyl group, lacking in the 3′ position of its ribose moiety. Cordycepin is known for various nutraceutical and therapeutic potential, such as anti-diabetic, anti-hyperlipidemia, anti-fungal, anti-inflammatory, immunomodulatory, antioxidant, anti-aging, anticancer, antiviral, hepato-protective, hypo-sexuality, cardiovascular diseases, antimalarial, anti-osteoporotic, anti-arthritic, cosmeceutical etc. which makes it a most valuable medicinal mushroom for helping in maintaining good health. In this review, effort has been made to bring altogether the possible wide range of cordycepin’s nutraceutical potential along with its pharmacological actions and possible mechanism. Additionally, it also summarizes the details of cordycepin based nutraceuticals predominantly available in the market with expected global value. Moreover, this review will attract the attention of food scientists, nutritionists, pharmaceutical and food industries to improve the use of bioactive molecule cordycepin for nutraceutical purposes with commercialization to aid and promote healthy lifestyle, wellness and wellbeing.https://www.mdpi.com/1420-3049/25/12/2735<i>Cordyceps</i>cordycepinmedicinal mushroomnutraceuticalanti-diabeticimmunomodulator |
| spellingShingle | Syed Amir Ashraf Abd Elmoneim O. Elkhalifa Arif Jamal Siddiqui Mitesh Patel Amir Mahgoub Awadelkareem Mejdi Snoussi Mohammad Saquib Ashraf Mohd Adnan Sibte Hadi Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus <i>Cordyceps</i> with Its Nutraceutical and Therapeutic Potential Molecules <i>Cordyceps</i> cordycepin medicinal mushroom nutraceutical anti-diabetic immunomodulator |
| title | Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus <i>Cordyceps</i> with Its Nutraceutical and Therapeutic Potential |
| title_full | Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus <i>Cordyceps</i> with Its Nutraceutical and Therapeutic Potential |
| title_fullStr | Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus <i>Cordyceps</i> with Its Nutraceutical and Therapeutic Potential |
| title_full_unstemmed | Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus <i>Cordyceps</i> with Its Nutraceutical and Therapeutic Potential |
| title_short | Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus <i>Cordyceps</i> with Its Nutraceutical and Therapeutic Potential |
| title_sort | cordycepin for health and wellbeing a potent bioactive metabolite of an entomopathogenic medicinal fungus i cordyceps i with its nutraceutical and therapeutic potential |
| topic | <i>Cordyceps</i> cordycepin medicinal mushroom nutraceutical anti-diabetic immunomodulator |
| url | https://www.mdpi.com/1420-3049/25/12/2735 |
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