Biomarkers of intake for coffee, tea, and sweetened beverages
Abstract Non-alcoholic beverages are important sources of nutrients and bioactive compounds that may influence human health and increase or decrease the risk of chronic diseases. A wide variety of beverage constituents are absorbed in the gut, found in the systemic circulation and excreted in urine....
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-07-01
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| Series: | Genes & Nutrition |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12263-018-0607-5 |
| _version_ | 1828340801764065280 |
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| author | Joseph A. Rothwell Francisco Madrid-Gambin Mar Garcia-Aloy Cristina Andres-Lacueva Caomhan Logue Alison M. Gallagher Carina Mack Sabine E. Kulling Qian Gao Giulia Praticò Lars O. Dragsted Augustin Scalbert |
| author_facet | Joseph A. Rothwell Francisco Madrid-Gambin Mar Garcia-Aloy Cristina Andres-Lacueva Caomhan Logue Alison M. Gallagher Carina Mack Sabine E. Kulling Qian Gao Giulia Praticò Lars O. Dragsted Augustin Scalbert |
| author_sort | Joseph A. Rothwell |
| collection | DOAJ |
| description | Abstract Non-alcoholic beverages are important sources of nutrients and bioactive compounds that may influence human health and increase or decrease the risk of chronic diseases. A wide variety of beverage constituents are absorbed in the gut, found in the systemic circulation and excreted in urine. They may be used as compliance markers in intervention studies or as biomarkers of intake to improve measurements of beverage consumption in cohort studies and reveal new associations with disease outcomes that may have been overlooked when using dietary questionnaires. Here, biomarkers of intake of some major non-alcoholic beverages—coffee, tea, sugar-sweetened beverages, and low-calorie-sweetened beverages—are reviewed. Results from dietary intervention studies and observational studies are reviewed and analyzed, and respective strengths and weaknesses of the various identified biomarkers discussed. A variety of compounds derived from phenolic acids, alkaloids, and terpenes were shown to be associated with coffee intake and trigonelline and cyclo(isoleucylprolyl) showed a particularly high specificity for coffee intake. Epigallocatechin and 4′-O-methylepigallocatechin appear to be the most sensitive and specific biomarkers for green or black tea, while 4-O-methylgallic acid may be used to assess black tea consumption. Intake of sugar-sweetened beverages has been assessed through the measurement of carbon-13 enrichment of whole blood or of blood alanine in North America where sugar from sugarcane or corn is used as a main ingredient. The most useful biomarkers for low-calorie-sweetened beverages are the low-calorie sweeteners themselves. Further studies are needed to validate these biomarkers in larger and independent populations and to further evaluate their specificity, reproducibility over time, and fields of application. |
| first_indexed | 2024-04-13T23:01:37Z |
| format | Article |
| id | doaj.art-4f0a563e71c44b408cbcbe6c86007cfd |
| institution | Directory Open Access Journal |
| issn | 1555-8932 1865-3499 |
| language | English |
| last_indexed | 2024-04-13T23:01:37Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Genes & Nutrition |
| spelling | doaj.art-4f0a563e71c44b408cbcbe6c86007cfd2022-12-22T02:25:49ZengBMCGenes & Nutrition1555-89321865-34992018-07-0113111810.1186/s12263-018-0607-5Biomarkers of intake for coffee, tea, and sweetened beveragesJoseph A. Rothwell0Francisco Madrid-Gambin1Mar Garcia-Aloy2Cristina Andres-Lacueva3Caomhan Logue4Alison M. Gallagher5Carina Mack6Sabine E. Kulling7Qian Gao8Giulia Praticò9Lars O. Dragsted10Augustin Scalbert11International Agency for Research on Cancer (IARC), Nutrition and Metabolism Section, Biomarkers GroupBiomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Campus Torribera, Faculty of Pharmacy and Food Sciences, University of BarcelonaBiomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Campus Torribera, Faculty of Pharmacy and Food Sciences, University of BarcelonaBiomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Campus Torribera, Faculty of Pharmacy and Food Sciences, University of BarcelonaNutrition Innovation Centre for Food and Health (NICHE), Biomedical Sciences Research Institute, Ulster UniversityNutrition Innovation Centre for Food and Health (NICHE), Biomedical Sciences Research Institute, Ulster UniversityDepartment of Safety and Quality of Fruit and Vegetables, Federal Research Institute of Nutrition and Food, Max Rubner-InstitutDepartment of Safety and Quality of Fruit and Vegetables, Federal Research Institute of Nutrition and Food, Max Rubner-InstitutDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of CopenhagenDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of CopenhagenDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of CopenhagenInternational Agency for Research on Cancer (IARC), Nutrition and Metabolism Section, Biomarkers GroupAbstract Non-alcoholic beverages are important sources of nutrients and bioactive compounds that may influence human health and increase or decrease the risk of chronic diseases. A wide variety of beverage constituents are absorbed in the gut, found in the systemic circulation and excreted in urine. They may be used as compliance markers in intervention studies or as biomarkers of intake to improve measurements of beverage consumption in cohort studies and reveal new associations with disease outcomes that may have been overlooked when using dietary questionnaires. Here, biomarkers of intake of some major non-alcoholic beverages—coffee, tea, sugar-sweetened beverages, and low-calorie-sweetened beverages—are reviewed. Results from dietary intervention studies and observational studies are reviewed and analyzed, and respective strengths and weaknesses of the various identified biomarkers discussed. A variety of compounds derived from phenolic acids, alkaloids, and terpenes were shown to be associated with coffee intake and trigonelline and cyclo(isoleucylprolyl) showed a particularly high specificity for coffee intake. Epigallocatechin and 4′-O-methylepigallocatechin appear to be the most sensitive and specific biomarkers for green or black tea, while 4-O-methylgallic acid may be used to assess black tea consumption. Intake of sugar-sweetened beverages has been assessed through the measurement of carbon-13 enrichment of whole blood or of blood alanine in North America where sugar from sugarcane or corn is used as a main ingredient. The most useful biomarkers for low-calorie-sweetened beverages are the low-calorie sweeteners themselves. Further studies are needed to validate these biomarkers in larger and independent populations and to further evaluate their specificity, reproducibility over time, and fields of application.http://link.springer.com/article/10.1186/s12263-018-0607-5Non-alcoholic beveragesCoffeeTeaSugar-sweetened beveragesLow-calorie-sweetened beveragesBiomarkers |
| spellingShingle | Joseph A. Rothwell Francisco Madrid-Gambin Mar Garcia-Aloy Cristina Andres-Lacueva Caomhan Logue Alison M. Gallagher Carina Mack Sabine E. Kulling Qian Gao Giulia Praticò Lars O. Dragsted Augustin Scalbert Biomarkers of intake for coffee, tea, and sweetened beverages Genes & Nutrition Non-alcoholic beverages Coffee Tea Sugar-sweetened beverages Low-calorie-sweetened beverages Biomarkers |
| title | Biomarkers of intake for coffee, tea, and sweetened beverages |
| title_full | Biomarkers of intake for coffee, tea, and sweetened beverages |
| title_fullStr | Biomarkers of intake for coffee, tea, and sweetened beverages |
| title_full_unstemmed | Biomarkers of intake for coffee, tea, and sweetened beverages |
| title_short | Biomarkers of intake for coffee, tea, and sweetened beverages |
| title_sort | biomarkers of intake for coffee tea and sweetened beverages |
| topic | Non-alcoholic beverages Coffee Tea Sugar-sweetened beverages Low-calorie-sweetened beverages Biomarkers |
| url | http://link.springer.com/article/10.1186/s12263-018-0607-5 |
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