Sendai virus-based immunoadjuvant in hydrogel vaccine intensity-modulated dendritic cells activation for suppressing tumorigenesis
The conventional immunoadjuvants in vaccine have weak effect on stimulating antigen presentation and activating anti-tumor immunity. Unexpectedly, we discovered that non-pathogenic Sendai virus (SeV) could activate antigen-presenting cells (APCs) represented by dendritic cells (DCs). Here, we design...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2021-11-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21001596 |
| _version_ | 1797203091120979968 |
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| author | Bin Zheng Wenchang Peng Lin Gan Mingming Guo Shuchao Wang Xiao-Dong Zhang Dong Ming |
| author_facet | Bin Zheng Wenchang Peng Lin Gan Mingming Guo Shuchao Wang Xiao-Dong Zhang Dong Ming |
| author_sort | Bin Zheng |
| collection | DOAJ |
| description | The conventional immunoadjuvants in vaccine have weak effect on stimulating antigen presentation and activating anti-tumor immunity. Unexpectedly, we discovered that non-pathogenic Sendai virus (SeV) could activate antigen-presenting cells (APCs) represented by dendritic cells (DCs). Here, we designed an injectable SeV-based hydrogel vaccine (SHV) to execute multi-channel recruitment and stimulation of DCs for boosting the specific immune response against tumors. After the release of the NIR-triggered antigens from tumor cells, dendritic cells around the vaccine efficiently transport the antigens to lymph nodes and present them to T lymphocytes, thereby inducing systemic anti-tumor immune memory. Our findings demonstrated that the SHV with excellent universality, convenience and flexibility has achieved better immune protection effects in inhibiting the occurrence of melanoma and breast cancer. In conclusion, the SHV system might serve as the next generation of personalized anti-tumor vaccines with enhanced features over standard vaccination regimens, and represented an alternative way to suppress tumorigenesis. |
| first_indexed | 2024-04-24T08:13:49Z |
| format | Article |
| id | doaj.art-4f0b84fd0b2848ac9c2bccabc008701b |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:13:49Z |
| publishDate | 2021-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-4f0b84fd0b2848ac9c2bccabc008701b2024-04-17T04:40:22ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2021-11-0161138793891Sendai virus-based immunoadjuvant in hydrogel vaccine intensity-modulated dendritic cells activation for suppressing tumorigenesisBin Zheng0Wenchang Peng1Lin Gan2Mingming Guo3Shuchao Wang4Xiao-Dong Zhang5Dong Ming6Academy of Medical Engineering and Translational Medicine, Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, China; Corresponding author.Academy of Medical Engineering and Translational Medicine, Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, ChinaSchool of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin, 300072, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, ChinaAcademy of Medical Engineering and Translational Medicine, Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, China; School of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin, 300072, China; Corresponding author. Academy of Medical Engineering and Translational Medicine, Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, China.The conventional immunoadjuvants in vaccine have weak effect on stimulating antigen presentation and activating anti-tumor immunity. Unexpectedly, we discovered that non-pathogenic Sendai virus (SeV) could activate antigen-presenting cells (APCs) represented by dendritic cells (DCs). Here, we designed an injectable SeV-based hydrogel vaccine (SHV) to execute multi-channel recruitment and stimulation of DCs for boosting the specific immune response against tumors. After the release of the NIR-triggered antigens from tumor cells, dendritic cells around the vaccine efficiently transport the antigens to lymph nodes and present them to T lymphocytes, thereby inducing systemic anti-tumor immune memory. Our findings demonstrated that the SHV with excellent universality, convenience and flexibility has achieved better immune protection effects in inhibiting the occurrence of melanoma and breast cancer. In conclusion, the SHV system might serve as the next generation of personalized anti-tumor vaccines with enhanced features over standard vaccination regimens, and represented an alternative way to suppress tumorigenesis.http://www.sciencedirect.com/science/article/pii/S2452199X21001596Hydrogel vaccineSendai virus (SeV)ImmunoadjuvantDendritic cellsImmunoprotection |
| spellingShingle | Bin Zheng Wenchang Peng Lin Gan Mingming Guo Shuchao Wang Xiao-Dong Zhang Dong Ming Sendai virus-based immunoadjuvant in hydrogel vaccine intensity-modulated dendritic cells activation for suppressing tumorigenesis Bioactive Materials Hydrogel vaccine Sendai virus (SeV) Immunoadjuvant Dendritic cells Immunoprotection |
| title | Sendai virus-based immunoadjuvant in hydrogel vaccine intensity-modulated dendritic cells activation for suppressing tumorigenesis |
| title_full | Sendai virus-based immunoadjuvant in hydrogel vaccine intensity-modulated dendritic cells activation for suppressing tumorigenesis |
| title_fullStr | Sendai virus-based immunoadjuvant in hydrogel vaccine intensity-modulated dendritic cells activation for suppressing tumorigenesis |
| title_full_unstemmed | Sendai virus-based immunoadjuvant in hydrogel vaccine intensity-modulated dendritic cells activation for suppressing tumorigenesis |
| title_short | Sendai virus-based immunoadjuvant in hydrogel vaccine intensity-modulated dendritic cells activation for suppressing tumorigenesis |
| title_sort | sendai virus based immunoadjuvant in hydrogel vaccine intensity modulated dendritic cells activation for suppressing tumorigenesis |
| topic | Hydrogel vaccine Sendai virus (SeV) Immunoadjuvant Dendritic cells Immunoprotection |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X21001596 |
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