Myeloid Sarcoma Type of Acute Promyelocytic Leukemia With a Cryptic Insertion of RARA Into FIP1L1: The Clinical Utility of NGS and Bioinformatic Analyses

Myeloid Sarcoma Type of Acute Promyelocytic Leukemia With a Cryptic Insertion of RARA Into FIP1L1: The Clinical Utility of NGS and Bioinformatic Analyses

BackgroundAcute promyelocytic leukemia (APL) is characterized by the presence of coagulopathy at onset and translocation t (15; 17) (q22; 21), meanwhile, other translocation variants of APL have also been reported. The FIP1L1–RARA fusion gene has recently been reported as a novel RARA-associated fus...

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Bibliographic Details
Main Authors: Yongren Wang, Yaoyao Rui, Ying Shen, Jian Li, Poning Liu, Qin Lu, Yongjun Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
acute promyelocytic leukemia
myeloid sarcoma
FIP1L1–RARA fusion
next-generation sequencing
KRAS gene
bioinformatic analyses
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.688203/full

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