Reviewing fair subject selection considerations for the unique case of post sequelae COVID-19 translational studies
Fair inclusion of research subjects is necessary to ensure that post-acute sequelae COVID-19 (PASC) research results benefit all members of society. Scientists should conduct research on a broad sample of individuals who represent clinically relevant factors influencing a disease. Without demographi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-01-01
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| Series: | Journal of Clinical and Translational Science |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866122004253/type/journal_article |
| _version_ | 1811156554601201664 |
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| author | E.M. Smith E.E. Anderson R. Deer J. Prochaska K. Bohn S. Croisant |
| author_facet | E.M. Smith E.E. Anderson R. Deer J. Prochaska K. Bohn S. Croisant |
| author_sort | E.M. Smith |
| collection | DOAJ |
| description | Fair inclusion of research subjects is necessary to ensure that post-acute sequelae COVID-19 (PASC) research results benefit all members of society. Scientists should conduct research on a broad sample of individuals who represent clinically relevant factors influencing a disease. Without demographic diversity and sociological and environmental variability, research outputs are less likely to apply to different populations and would thus increase health disparities. The goal of this narrative literature review and ethical analysis is to apply fair selection criteria to PASC research studies. We briefly highlight the importance of fair subject selection in translational research and then identify features of PASC, as well as PASC research, that hinder fair inclusion of research participants. We will demonstrate that determining an adequate and representative sample is not simply a matter of ensuring greater diversity; rather, fairness requires a broader evaluation of risks, burdens, and benefits specific to underrepresented populations. We provide recommendations to ensure fair subject selection in PASC research and promote translation toward positive health outcomes for all individuals, including the most vulnerable. |
| first_indexed | 2024-04-10T04:52:32Z |
| format | Article |
| id | doaj.art-4f0d36f2f1ec49c4bf0723634456fb92 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-10T04:52:32Z |
| publishDate | 2022-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-4f0d36f2f1ec49c4bf0723634456fb922023-03-09T12:31:04ZengCambridge University PressJournal of Clinical and Translational Science2059-86612022-01-01610.1017/cts.2022.425Reviewing fair subject selection considerations for the unique case of post sequelae COVID-19 translational studiesE.M. Smith0https://orcid.org/0000-0002-4615-8204E.E. Anderson1R. Deer2J. Prochaska3K. Bohn4S. Croisant5School of Public and Population Health, University of Texas Medical Branch, Galveston, TX, USA Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, USALoyola University Chicago Stritch School of Medicine, Maywood, IL, USASchool of Health Professions, University of Texas Medical Branch, Galveston, TX, USA this researcher has recently left UTMB and joined NovartisSchool of Public and Population Health, University of Texas Medical Branch, Galveston, TX, USA Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, USAInstitute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, USASchool of Public and Population Health, University of Texas Medical Branch, Galveston, TX, USA Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, USAFair inclusion of research subjects is necessary to ensure that post-acute sequelae COVID-19 (PASC) research results benefit all members of society. Scientists should conduct research on a broad sample of individuals who represent clinically relevant factors influencing a disease. Without demographic diversity and sociological and environmental variability, research outputs are less likely to apply to different populations and would thus increase health disparities. The goal of this narrative literature review and ethical analysis is to apply fair selection criteria to PASC research studies. We briefly highlight the importance of fair subject selection in translational research and then identify features of PASC, as well as PASC research, that hinder fair inclusion of research participants. We will demonstrate that determining an adequate and representative sample is not simply a matter of ensuring greater diversity; rather, fairness requires a broader evaluation of risks, burdens, and benefits specific to underrepresented populations. We provide recommendations to ensure fair subject selection in PASC research and promote translation toward positive health outcomes for all individuals, including the most vulnerable.https://www.cambridge.org/core/product/identifier/S2059866122004253/type/journal_articlePost sequelae COVID-19research ethicsfair inclusionfair subject selectiondiversityrepresentation in research |
| spellingShingle | E.M. Smith E.E. Anderson R. Deer J. Prochaska K. Bohn S. Croisant Reviewing fair subject selection considerations for the unique case of post sequelae COVID-19 translational studies Journal of Clinical and Translational Science Post sequelae COVID-19 research ethics fair inclusion fair subject selection diversity representation in research |
| title | Reviewing fair subject selection considerations for the unique case of post sequelae COVID-19 translational studies |
| title_full | Reviewing fair subject selection considerations for the unique case of post sequelae COVID-19 translational studies |
| title_fullStr | Reviewing fair subject selection considerations for the unique case of post sequelae COVID-19 translational studies |
| title_full_unstemmed | Reviewing fair subject selection considerations for the unique case of post sequelae COVID-19 translational studies |
| title_short | Reviewing fair subject selection considerations for the unique case of post sequelae COVID-19 translational studies |
| title_sort | reviewing fair subject selection considerations for the unique case of post sequelae covid 19 translational studies |
| topic | Post sequelae COVID-19 research ethics fair inclusion fair subject selection diversity representation in research |
| url | https://www.cambridge.org/core/product/identifier/S2059866122004253/type/journal_article |
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