Histone deacetylase 4 protects from denervation and skeletal muscle atrophy in a murine model of amyotrophic lateral sclerosisResearch in context

Histone deacetylase 4 protects from denervation and skeletal muscle atrophy in a murine model of amyotrophic lateral sclerosisResearch in context

Background: Histone deacetylase 4 (HDAC4) has been proposed as a target for Amyotrophic Lateral Sclerosis (ALS) because it mediates nerve-skeletal muscle interaction and since its expression in skeletal muscle correlates with the severity of the disease. However, our recent studies on the skeletal m...

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Bibliographic Details
Main Authors: Eva Pigna, Elena Simonazzi, Krizia Sanna, Krzysztof Marian Bernadzki, Tomek Proszynski, Constantin Heil, Daniela Palacios, Sergio Adamo, Viviana Moresi
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419300441

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