Arabidopsis thaliana: a powerful model organism to explore histone modifications and their upstream regulations
Histones are subjected to extensive covalent modifications that affect inter-nucleosomal interactions as well as alter chromatin structure and DNA accessibility. Through switching the corresponding histone modifications, the level of transcription and diverse downstream biological processes can be r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15592294.2023.2211362 |
| _version_ | 1797678813544448000 |
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| author | Yang Yu Sihan Wang Ziqin Wang Renwei Gao Joohyun Lee |
| author_facet | Yang Yu Sihan Wang Ziqin Wang Renwei Gao Joohyun Lee |
| author_sort | Yang Yu |
| collection | DOAJ |
| description | Histones are subjected to extensive covalent modifications that affect inter-nucleosomal interactions as well as alter chromatin structure and DNA accessibility. Through switching the corresponding histone modifications, the level of transcription and diverse downstream biological processes can be regulated. Although animal systems are widely used in studying histone modifications, the signalling processes that occur outside the nucleus prior to histone modifications have not been well understood due to the limitations including non viable mutants, partial lethality, and infertility of survivors. Here, we review the benefits of using Arabidopsis thaliana as the model organism to study histone modifications and their upstream regulations. Similarities among histones and key histone modifiers such as the Polycomb group (PcG) and Trithorax group (TrxG) in Drosophila, Human, and Arabidopsis are examined. Furthermore, prolonged cold-induced vernalization system has been well-studied and revealed the relationship between the controllable environment input (duration of vernalization), its chromatin modifications of FLOWERING LOCUS C (FLC), following gene expression, and the corresponding phenotypes. Such evidence suggests that research on Arabidopsis can bring insights into incomplete signalling pathways outside of the histone box, which can be achieved through viable reverse genetic screenings based on the phenotypes instead of direct monitoring of histone modifications among individual mutants. The potential upstream regulators in Arabidopsis can provide cues or directions for animal research based on the similarities between them. |
| first_indexed | 2024-03-11T23:05:23Z |
| format | Article |
| id | doaj.art-4f0dfcc6fff14881992e7640e2a1259f |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-11T23:05:23Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-4f0dfcc6fff14881992e7640e2a1259f2023-09-21T13:23:13ZengTaylor & Francis GroupEpigenetics1559-22941559-23082023-12-0118110.1080/15592294.2023.22113622211362Arabidopsis thaliana: a powerful model organism to explore histone modifications and their upstream regulationsYang Yu0Sihan Wang1Ziqin Wang2Renwei Gao3Joohyun Lee4Duke Kunshan UniversityDuke Kunshan UniversityDuke Kunshan UniversityDuke Kunshan UniversityDuke Kunshan UniversityHistones are subjected to extensive covalent modifications that affect inter-nucleosomal interactions as well as alter chromatin structure and DNA accessibility. Through switching the corresponding histone modifications, the level of transcription and diverse downstream biological processes can be regulated. Although animal systems are widely used in studying histone modifications, the signalling processes that occur outside the nucleus prior to histone modifications have not been well understood due to the limitations including non viable mutants, partial lethality, and infertility of survivors. Here, we review the benefits of using Arabidopsis thaliana as the model organism to study histone modifications and their upstream regulations. Similarities among histones and key histone modifiers such as the Polycomb group (PcG) and Trithorax group (TrxG) in Drosophila, Human, and Arabidopsis are examined. Furthermore, prolonged cold-induced vernalization system has been well-studied and revealed the relationship between the controllable environment input (duration of vernalization), its chromatin modifications of FLOWERING LOCUS C (FLC), following gene expression, and the corresponding phenotypes. Such evidence suggests that research on Arabidopsis can bring insights into incomplete signalling pathways outside of the histone box, which can be achieved through viable reverse genetic screenings based on the phenotypes instead of direct monitoring of histone modifications among individual mutants. The potential upstream regulators in Arabidopsis can provide cues or directions for animal research based on the similarities between them.http://dx.doi.org/10.1080/15592294.2023.2211362arabidopsis thalianamodel organismshistone modificationsepigenetics |
| spellingShingle | Yang Yu Sihan Wang Ziqin Wang Renwei Gao Joohyun Lee Arabidopsis thaliana: a powerful model organism to explore histone modifications and their upstream regulations Epigenetics arabidopsis thaliana model organisms histone modifications epigenetics |
| title | Arabidopsis thaliana: a powerful model organism to explore histone modifications and their upstream regulations |
| title_full | Arabidopsis thaliana: a powerful model organism to explore histone modifications and their upstream regulations |
| title_fullStr | Arabidopsis thaliana: a powerful model organism to explore histone modifications and their upstream regulations |
| title_full_unstemmed | Arabidopsis thaliana: a powerful model organism to explore histone modifications and their upstream regulations |
| title_short | Arabidopsis thaliana: a powerful model organism to explore histone modifications and their upstream regulations |
| title_sort | arabidopsis thaliana a powerful model organism to explore histone modifications and their upstream regulations |
| topic | arabidopsis thaliana model organisms histone modifications epigenetics |
| url | http://dx.doi.org/10.1080/15592294.2023.2211362 |
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