PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells

PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells

<p>Cytoplasmic expression of claudin-1 in metastatic melanoma cells correlates to increased migration, and increased secretion of MMP-2 in a PKC dependent manner, whereas claudin-1 nuclear expression is found in benign nevi. Melanoma cells were transfected with a vector expressing CLDN-1 fused...

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Bibliographic Details
Main Author: Amanda D. French, Jennifer L. Fiori, Tura C. Camilli, Poloko D. Leotlela, Michael P. O'Connell, Brittany P. Frank, Sarah Subaran, Fred. E. Indig, Dennis D. Taub, Ashani T. Weeraratna
Format: Article
Language:English
Published: Ivyspring International Publisher 2009-01-01
Series:International Journal of Medical Sciences
Online Access:http://www.medsci.org/v06p0093.htm

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