Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system
Neuromedin U (NMU) is a bioactive neuropeptide, highly distributed in the gastrointestinal tract and the central nervous system. NMU has various physiological functions related to feeding behavior, energy metabolism, stress responses, circadian rhythmicity and inflammation. Recently, several reports...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-05-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020307921 |
| _version_ | 1818931958643687424 |
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| author | Madoka Anan Ryoko Higa Kenshiro Shikano Masahito Shide Akinobu Soda Magdeline E. Carrasco Apolinario Kenji Mori Toshitaka Shin Mikiya Miyazato Hiromitsu Mimata Takatoshi Hikida Toshikatsu Hanada Kazuwa Nakao Kenji Kangawa Reiko Hanada |
| author_facet | Madoka Anan Ryoko Higa Kenshiro Shikano Masahito Shide Akinobu Soda Magdeline E. Carrasco Apolinario Kenji Mori Toshitaka Shin Mikiya Miyazato Hiromitsu Mimata Takatoshi Hikida Toshikatsu Hanada Kazuwa Nakao Kenji Kangawa Reiko Hanada |
| author_sort | Madoka Anan |
| collection | DOAJ |
| description | Neuromedin U (NMU) is a bioactive neuropeptide, highly distributed in the gastrointestinal tract and the central nervous system. NMU has various physiological functions related to feeding behavior, energy metabolism, stress responses, circadian rhythmicity and inflammation. Recently, several reports indicate that the central NMU system plays an important role in the reward systems in the brain. However, the underlying molecular mechanisms are not yet fully defined. In this study, we found that some of cocaine-induced c-Fos immunoreactive cells were co-localized with NMU in the nucleus accumbens (NAc), caudate putamen (CPu), and basolateral amygdala (BLA), which are key brain regions associated with the brain reward system, in wild type mice. Whereas, a treatment with cocaine did not influence the kinetics of NMU or NMU receptors mRNA expression in these brain regions, and NMU-knockout mice did not show any higher preference for cocaine compared with their control mice. These results indicate that cocaine has some effect on NMU expressing neurons related to the brain reward system, and this suggests NMU system may have a role on the brain reward systems activated by cocaine. |
| first_indexed | 2024-12-20T04:24:52Z |
| format | Article |
| id | doaj.art-4f0e8baf3e0044818528c244a4f8f1c4 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-20T04:24:52Z |
| publishDate | 2020-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-4f0e8baf3e0044818528c244a4f8f1c42022-12-21T19:53:33ZengElsevierHeliyon2405-84402020-05-0165e03947Cocaine has some effect on neuromedin U expressing neurons related to the brain reward systemMadoka Anan0Ryoko Higa1Kenshiro Shikano2Masahito Shide3Akinobu Soda4Magdeline E. Carrasco Apolinario5Kenji Mori6Toshitaka Shin7Mikiya Miyazato8Hiromitsu Mimata9Takatoshi Hikida10Toshikatsu Hanada11Kazuwa Nakao12Kenji Kangawa13Reiko Hanada14Department of Neurophysiology, Faculty of Medicine, Oita University, Oita, JapanDepartment of Neurophysiology, Faculty of Medicine, Oita University, Oita, JapanDepartment of Neurophysiology, Faculty of Medicine, Oita University, Oita, JapanDepartment of Neurophysiology, Faculty of Medicine, Oita University, Oita, JapanDepartment of Neurophysiology, Faculty of Medicine, Oita University, Oita, JapanDepartment of Neurophysiology, Faculty of Medicine, Oita University, Oita, JapanDepartment of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Osaka, JapanDepartment of Urology, Faculty of Medicine, Oita University, Oita, JapanDepartment of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Osaka, JapanDepartment of Urology, Faculty of Medicine, Oita University, Oita, JapanLaboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, Osaka, JapanDepartment of Cell Biology, Faculty of Medicine, Oita University, Oita, JapanMedical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, JapanDepartment of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Osaka, JapanDepartment of Neurophysiology, Faculty of Medicine, Oita University, Oita, Japan; Corresponding author.Neuromedin U (NMU) is a bioactive neuropeptide, highly distributed in the gastrointestinal tract and the central nervous system. NMU has various physiological functions related to feeding behavior, energy metabolism, stress responses, circadian rhythmicity and inflammation. Recently, several reports indicate that the central NMU system plays an important role in the reward systems in the brain. However, the underlying molecular mechanisms are not yet fully defined. In this study, we found that some of cocaine-induced c-Fos immunoreactive cells were co-localized with NMU in the nucleus accumbens (NAc), caudate putamen (CPu), and basolateral amygdala (BLA), which are key brain regions associated with the brain reward system, in wild type mice. Whereas, a treatment with cocaine did not influence the kinetics of NMU or NMU receptors mRNA expression in these brain regions, and NMU-knockout mice did not show any higher preference for cocaine compared with their control mice. These results indicate that cocaine has some effect on NMU expressing neurons related to the brain reward system, and this suggests NMU system may have a role on the brain reward systems activated by cocaine.http://www.sciencedirect.com/science/article/pii/S2405844020307921NeurosciencePhysiologyEndocrinologyAddiction medicineBehavioral medicineBiological psychiatry |
| spellingShingle | Madoka Anan Ryoko Higa Kenshiro Shikano Masahito Shide Akinobu Soda Magdeline E. Carrasco Apolinario Kenji Mori Toshitaka Shin Mikiya Miyazato Hiromitsu Mimata Takatoshi Hikida Toshikatsu Hanada Kazuwa Nakao Kenji Kangawa Reiko Hanada Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system Heliyon Neuroscience Physiology Endocrinology Addiction medicine Behavioral medicine Biological psychiatry |
| title | Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system |
| title_full | Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system |
| title_fullStr | Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system |
| title_full_unstemmed | Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system |
| title_short | Cocaine has some effect on neuromedin U expressing neurons related to the brain reward system |
| title_sort | cocaine has some effect on neuromedin u expressing neurons related to the brain reward system |
| topic | Neuroscience Physiology Endocrinology Addiction medicine Behavioral medicine Biological psychiatry |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020307921 |
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