Mesenchymal stem cell-derived exosomes as delivery vehicles for non-coding RNAs in lung diseases
The burden of lung diseases is gradually increasing with an increase in the average human life expectancy. Therefore, it is necessary to identify effective methods to treat lung diseases and reduce their social burden. Currently, an increasing number of studies focus on the role of mesenchymal stem...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223018061 |
| _version_ | 1797364290938732544 |
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| author | Yuqian Feng Kaibo Guo Jing Jiang Shengyou Lin |
| author_facet | Yuqian Feng Kaibo Guo Jing Jiang Shengyou Lin |
| author_sort | Yuqian Feng |
| collection | DOAJ |
| description | The burden of lung diseases is gradually increasing with an increase in the average human life expectancy. Therefore, it is necessary to identify effective methods to treat lung diseases and reduce their social burden. Currently, an increasing number of studies focus on the role of mesenchymal stem cell-derived exosomes (MSC-Exos) as a cell-free therapy in lung diseases. They show great potential for application to lung diseases as a more stable and safer option than traditional cell therapies. MSC-Exos are rich in various substances, including proteins, nucleic acids, and DNA. Delivery of Non-coding RNAs (ncRNAs) enables MSC-Exos to communicate with target cells. MSC-Exos significantly inhibit inflammatory factors, reduce oxidative stress, promote normal lung cell proliferation, and reduce apoptosis by delivering ncRNAs. Moreover, MSC-Exos carrying specific ncRNAs affect the proliferation, invasion, and migration of lung cancer cells, thereby playing a role in managing lung cancer. The detailed mechanisms of MSC-Exos in the clinical treatment of lung disease were explored by developing standardized culture, isolation, purification, and administration strategies. In summary, MSC-Exo-based delivery methods have important application prospects for treating lung diseases. |
| first_indexed | 2024-03-08T16:33:10Z |
| format | Article |
| id | doaj.art-4f0ebcf2c786429a8bdf4d6ff2735e66 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-08T16:33:10Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-4f0ebcf2c786429a8bdf4d6ff2735e662024-01-06T04:37:53ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-01-01170116008Mesenchymal stem cell-derived exosomes as delivery vehicles for non-coding RNAs in lung diseasesYuqian Feng0Kaibo Guo1Jing Jiang2Shengyou Lin3Hangzhou School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, ChinaDepartment of Oncology, Hangzhou First People’s Hospital, Hangzhou, Zhejiang 310003, ChinaThe Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, ChinaDepartment of Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang 310006, China; Corresponding author.The burden of lung diseases is gradually increasing with an increase in the average human life expectancy. Therefore, it is necessary to identify effective methods to treat lung diseases and reduce their social burden. Currently, an increasing number of studies focus on the role of mesenchymal stem cell-derived exosomes (MSC-Exos) as a cell-free therapy in lung diseases. They show great potential for application to lung diseases as a more stable and safer option than traditional cell therapies. MSC-Exos are rich in various substances, including proteins, nucleic acids, and DNA. Delivery of Non-coding RNAs (ncRNAs) enables MSC-Exos to communicate with target cells. MSC-Exos significantly inhibit inflammatory factors, reduce oxidative stress, promote normal lung cell proliferation, and reduce apoptosis by delivering ncRNAs. Moreover, MSC-Exos carrying specific ncRNAs affect the proliferation, invasion, and migration of lung cancer cells, thereby playing a role in managing lung cancer. The detailed mechanisms of MSC-Exos in the clinical treatment of lung disease were explored by developing standardized culture, isolation, purification, and administration strategies. In summary, MSC-Exo-based delivery methods have important application prospects for treating lung diseases.http://www.sciencedirect.com/science/article/pii/S0753332223018061ExosomesMesenchymal stem cellsNon-coding RNAsLung disease |
| spellingShingle | Yuqian Feng Kaibo Guo Jing Jiang Shengyou Lin Mesenchymal stem cell-derived exosomes as delivery vehicles for non-coding RNAs in lung diseases Biomedicine & Pharmacotherapy Exosomes Mesenchymal stem cells Non-coding RNAs Lung disease |
| title | Mesenchymal stem cell-derived exosomes as delivery vehicles for non-coding RNAs in lung diseases |
| title_full | Mesenchymal stem cell-derived exosomes as delivery vehicles for non-coding RNAs in lung diseases |
| title_fullStr | Mesenchymal stem cell-derived exosomes as delivery vehicles for non-coding RNAs in lung diseases |
| title_full_unstemmed | Mesenchymal stem cell-derived exosomes as delivery vehicles for non-coding RNAs in lung diseases |
| title_short | Mesenchymal stem cell-derived exosomes as delivery vehicles for non-coding RNAs in lung diseases |
| title_sort | mesenchymal stem cell derived exosomes as delivery vehicles for non coding rnas in lung diseases |
| topic | Exosomes Mesenchymal stem cells Non-coding RNAs Lung disease |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223018061 |
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