Detection of invasive Bartonella infections with next-generation sequencing of microbial cell-free DNA
We report 9 patients with invasive Bartonella infections, including 5 with endocarditis, who were diagnosed with microbial cell-free DNA next-generation sequencing and Bartonella serology studies. Diagnosis with plasma mcfDNA NGS enabled a faster clinical and laboratory diagnosis in 8 patients. Prom...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-01-01
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| Series: | Antimicrobial Stewardship & Healthcare Epidemiology |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2732494X24000160/type/journal_article |
| _version_ | 1797316518250283008 |
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| author | Fernando H Centeno Ahmed M. Hamdi Todd M. Lasco Mayar Al Mohajer |
| author_facet | Fernando H Centeno Ahmed M. Hamdi Todd M. Lasco Mayar Al Mohajer |
| author_sort | Fernando H Centeno |
| collection | DOAJ |
| description | We report 9 patients with invasive Bartonella infections, including 5 with endocarditis, who were diagnosed with microbial cell-free DNA next-generation sequencing and Bartonella serology studies. Diagnosis with plasma mcfDNA NGS enabled a faster clinical and laboratory diagnosis in 8 patients. Prompt diagnosis impacted antibiotic management in all 9 patients. |
| first_indexed | 2024-03-08T03:20:31Z |
| format | Article |
| id | doaj.art-4f0fe7558c5145d68196c6f38970700d |
| institution | Directory Open Access Journal |
| issn | 2732-494X |
| language | English |
| last_indexed | 2024-03-08T03:20:31Z |
| publishDate | 2024-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Antimicrobial Stewardship & Healthcare Epidemiology |
| spelling | doaj.art-4f0fe7558c5145d68196c6f38970700d2024-02-12T10:26:39ZengCambridge University PressAntimicrobial Stewardship & Healthcare Epidemiology2732-494X2024-01-01410.1017/ash.2024.16Detection of invasive Bartonella infections with next-generation sequencing of microbial cell-free DNAFernando H Centeno0https://orcid.org/0000-0003-3122-6830Ahmed M. Hamdi1https://orcid.org/0000-0002-5624-5985Todd M. Lasco2Mayar Al Mohajer3Department of Medicine, Baylor College of Medicine, Houston, TX, USADepartment of Medicine, Baylor College of Medicine, Houston, TX, USA Baylor St. Luke’s Medical Center, Houston, TX, USADepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA Baylor St. Luke’s Medical Center, Houston, TX, USADepartment of Medicine, Baylor College of Medicine, Houston, TX, USA Baylor St. Luke’s Medical Center, Houston, TX, USAWe report 9 patients with invasive Bartonella infections, including 5 with endocarditis, who were diagnosed with microbial cell-free DNA next-generation sequencing and Bartonella serology studies. Diagnosis with plasma mcfDNA NGS enabled a faster clinical and laboratory diagnosis in 8 patients. Prompt diagnosis impacted antibiotic management in all 9 patients.https://www.cambridge.org/core/product/identifier/S2732494X24000160/type/journal_article |
| spellingShingle | Fernando H Centeno Ahmed M. Hamdi Todd M. Lasco Mayar Al Mohajer Detection of invasive Bartonella infections with next-generation sequencing of microbial cell-free DNA Antimicrobial Stewardship & Healthcare Epidemiology |
| title | Detection of invasive Bartonella infections with next-generation sequencing of microbial cell-free DNA |
| title_full | Detection of invasive Bartonella infections with next-generation sequencing of microbial cell-free DNA |
| title_fullStr | Detection of invasive Bartonella infections with next-generation sequencing of microbial cell-free DNA |
| title_full_unstemmed | Detection of invasive Bartonella infections with next-generation sequencing of microbial cell-free DNA |
| title_short | Detection of invasive Bartonella infections with next-generation sequencing of microbial cell-free DNA |
| title_sort | detection of invasive bartonella infections with next generation sequencing of microbial cell free dna |
| url | https://www.cambridge.org/core/product/identifier/S2732494X24000160/type/journal_article |
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