Association between HDL levels and stroke outcomes in the Arab population
Abstract Low HDL levels are associated with an increased stroke incidence and worsened long-term outcomes. The aim of this study was to assess the relationship between HDL levels and long-term stroke outcomes in the Arab population. Patients admitted to the Qatar Stroke Database between 2014 and 202...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-53613-z |
| _version_ | 1797274769124491264 |
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| author | Aizaz Ali Omar Obaid Naveed Akhtar Rahul Rao Syed Haroon Tora Ashfaq Shuaib |
| author_facet | Aizaz Ali Omar Obaid Naveed Akhtar Rahul Rao Syed Haroon Tora Ashfaq Shuaib |
| author_sort | Aizaz Ali |
| collection | DOAJ |
| description | Abstract Low HDL levels are associated with an increased stroke incidence and worsened long-term outcomes. The aim of this study was to assess the relationship between HDL levels and long-term stroke outcomes in the Arab population. Patients admitted to the Qatar Stroke Database between 2014 and 2022 were included in the study and stratified into sex-specific HDL quartiles. Long-term outcomes included 90-Day modified Rankin Score (mRS), stroke recurrence, and post-stroke cardiovascular complications within 1 year of discharge. Multivariate binary logistic regression analyses were performed to identify the independent effect of HDL levels on short- and long-term outcomes. On multivariate binary logistic regression analyses, 1-year stroke recurrence was 2.24 times higher (p = 0.034) and MACE was 1.99 times higher (p = 0.009) in the low-HDL compared to the high-HDL group. Mortality at 1 year was 2.27-fold in the low-normal HDL group compared to the reference group (p = 0.049). Lower sex-specific HDL levels were independently associated with higher adjusted odds of 1-year post-stroke mortality, stroke recurrence, and MACE (p < 0.05). In patients who suffer a stroke, low HDL levels are associated with a higher risk of subsequent vascular complication. |
| first_indexed | 2024-03-07T15:03:15Z |
| format | Article |
| id | doaj.art-4f1044292b6542e29c0aa7464b46d6e2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:03:15Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4f1044292b6542e29c0aa7464b46d6e22024-03-05T19:01:47ZengNature PortfolioScientific Reports2045-23222024-02-011411910.1038/s41598-024-53613-zAssociation between HDL levels and stroke outcomes in the Arab populationAizaz Ali0Omar Obaid1Naveed Akhtar2Rahul Rao3Syed Haroon Tora4Ashfaq Shuaib5Department of Neurology, University of Toledo Medical CenterDepartment of General Surgery, University of Toledo Medical CenterDepartment of Neurology, Hamad Medical CorporationDepartment of Neurology, University of Toledo Medical CenterMaster of Public Health Candidate, Bloomberg School of Public Health, Johns Hopkins UniversityUniversity of Alberta, NeurologyAbstract Low HDL levels are associated with an increased stroke incidence and worsened long-term outcomes. The aim of this study was to assess the relationship between HDL levels and long-term stroke outcomes in the Arab population. Patients admitted to the Qatar Stroke Database between 2014 and 2022 were included in the study and stratified into sex-specific HDL quartiles. Long-term outcomes included 90-Day modified Rankin Score (mRS), stroke recurrence, and post-stroke cardiovascular complications within 1 year of discharge. Multivariate binary logistic regression analyses were performed to identify the independent effect of HDL levels on short- and long-term outcomes. On multivariate binary logistic regression analyses, 1-year stroke recurrence was 2.24 times higher (p = 0.034) and MACE was 1.99 times higher (p = 0.009) in the low-HDL compared to the high-HDL group. Mortality at 1 year was 2.27-fold in the low-normal HDL group compared to the reference group (p = 0.049). Lower sex-specific HDL levels were independently associated with higher adjusted odds of 1-year post-stroke mortality, stroke recurrence, and MACE (p < 0.05). In patients who suffer a stroke, low HDL levels are associated with a higher risk of subsequent vascular complication.https://doi.org/10.1038/s41598-024-53613-zHigh density lipoproteinStrokePost-stroke outcomesMACECerebral infarctionEpidemiology |
| spellingShingle | Aizaz Ali Omar Obaid Naveed Akhtar Rahul Rao Syed Haroon Tora Ashfaq Shuaib Association between HDL levels and stroke outcomes in the Arab population Scientific Reports High density lipoprotein Stroke Post-stroke outcomes MACE Cerebral infarction Epidemiology |
| title | Association between HDL levels and stroke outcomes in the Arab population |
| title_full | Association between HDL levels and stroke outcomes in the Arab population |
| title_fullStr | Association between HDL levels and stroke outcomes in the Arab population |
| title_full_unstemmed | Association between HDL levels and stroke outcomes in the Arab population |
| title_short | Association between HDL levels and stroke outcomes in the Arab population |
| title_sort | association between hdl levels and stroke outcomes in the arab population |
| topic | High density lipoprotein Stroke Post-stroke outcomes MACE Cerebral infarction Epidemiology |
| url | https://doi.org/10.1038/s41598-024-53613-z |
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