Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression.
Low Clostridium leptum levels are a risk factor for the development of asthma. C. leptum deficiency exacerbates asthma; however, the impact of early-life C. leptum exposure on cesarean-delivered mice remains unclear. This study is to determine the effects of early-life C. leptum exposure on asthma d...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4643994?pdf=render |
| _version_ | 1828837230089601024 |
|---|---|
| author | Fei Huang Hong-Mei Qiao Jia-Ning Yin Yang Gao Yang-Hua Ju Ya-Nan Li |
| author_facet | Fei Huang Hong-Mei Qiao Jia-Ning Yin Yang Gao Yang-Hua Ju Ya-Nan Li |
| author_sort | Fei Huang |
| collection | DOAJ |
| description | Low Clostridium leptum levels are a risk factor for the development of asthma. C. leptum deficiency exacerbates asthma; however, the impact of early-life C. leptum exposure on cesarean-delivered mice remains unclear. This study is to determine the effects of early-life C. leptum exposure on asthma development in infant mice.We exposed infant mice to C. leptum (fed-CL) and then induced asthma using the allergen ovalbumin (OVA).Fed-CL increased regulatory T (Treg) cells in cesarean-delivered mice compared with vaginally delivered mice. Compared with OVA-exposed mice, mice exposed to C. leptum + OVA did not develop the typical asthma phenotype, which includes airway hyper-responsiveness, cell infiltration, and T helper cell subset (Th1, Th2, Th9, Th17) inflammation. Early-life C. leptum exposure induced an immunosuppressive environment in the lung concurrent with increased Treg cells, resulting in the inhibition of Th1, Th2, Th9, and Th17 cell responses.These findings demonstrate a mechanism whereby C. leptum exposure modulates adaptive immunity and leads to failure to develop asthma upon OVA sensitization later in life. |
| first_indexed | 2024-12-12T18:37:50Z |
| format | Article |
| id | doaj.art-4f134375f52e4a56a40e66541ba9eed8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T18:37:50Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4f134375f52e4a56a40e66541ba9eed82022-12-22T00:15:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011011e014171710.1371/journal.pone.0141717Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression.Fei HuangHong-Mei QiaoJia-Ning YinYang GaoYang-Hua JuYa-Nan LiLow Clostridium leptum levels are a risk factor for the development of asthma. C. leptum deficiency exacerbates asthma; however, the impact of early-life C. leptum exposure on cesarean-delivered mice remains unclear. This study is to determine the effects of early-life C. leptum exposure on asthma development in infant mice.We exposed infant mice to C. leptum (fed-CL) and then induced asthma using the allergen ovalbumin (OVA).Fed-CL increased regulatory T (Treg) cells in cesarean-delivered mice compared with vaginally delivered mice. Compared with OVA-exposed mice, mice exposed to C. leptum + OVA did not develop the typical asthma phenotype, which includes airway hyper-responsiveness, cell infiltration, and T helper cell subset (Th1, Th2, Th9, Th17) inflammation. Early-life C. leptum exposure induced an immunosuppressive environment in the lung concurrent with increased Treg cells, resulting in the inhibition of Th1, Th2, Th9, and Th17 cell responses.These findings demonstrate a mechanism whereby C. leptum exposure modulates adaptive immunity and leads to failure to develop asthma upon OVA sensitization later in life.http://europepmc.org/articles/PMC4643994?pdf=render |
| spellingShingle | Fei Huang Hong-Mei Qiao Jia-Ning Yin Yang Gao Yang-Hua Ju Ya-Nan Li Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. PLoS ONE |
| title | Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. |
| title_full | Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. |
| title_fullStr | Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. |
| title_full_unstemmed | Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. |
| title_short | Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. |
| title_sort | early life exposure to clostridium leptum causes pulmonary immunosuppression |
| url | http://europepmc.org/articles/PMC4643994?pdf=render |
| work_keys_str_mv | AT feihuang earlylifeexposuretoclostridiumleptumcausespulmonaryimmunosuppression AT hongmeiqiao earlylifeexposuretoclostridiumleptumcausespulmonaryimmunosuppression AT jianingyin earlylifeexposuretoclostridiumleptumcausespulmonaryimmunosuppression AT yanggao earlylifeexposuretoclostridiumleptumcausespulmonaryimmunosuppression AT yanghuaju earlylifeexposuretoclostridiumleptumcausespulmonaryimmunosuppression AT yananli earlylifeexposuretoclostridiumleptumcausespulmonaryimmunosuppression |