Clinical outcomes of initially asymptomatic patients with COVID-19: a Korean nationwide cohort study
AbstractBackground This study was performed to compare severe clinical outcome between initially asymptomatic and symptomatic infections and to identify risk factors associated with high patient mortality among initially asymptomatic patients.Methods In this retrospective, nationwide cohort study, w...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2021.1884744 |
| _version_ | 1797385691635646464 |
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| author | Hayne Cho Park Do Hyoung Kim Ajin Cho Juhee Kim Kyu-sang Yun Jinseog Kim Young-Ki Lee |
| author_facet | Hayne Cho Park Do Hyoung Kim Ajin Cho Juhee Kim Kyu-sang Yun Jinseog Kim Young-Ki Lee |
| author_sort | Hayne Cho Park |
| collection | DOAJ |
| description | AbstractBackground This study was performed to compare severe clinical outcome between initially asymptomatic and symptomatic infections and to identify risk factors associated with high patient mortality among initially asymptomatic patients.Methods In this retrospective, nationwide cohort study, we included 5621 patients who had been discharged from isolation or died from COVID-19 by 30 April 2020. The mortality rate and admission rate to intensive care unit (ICU) were compared between initially asymptomatic and symptomatic patients. We established a prediction model for patient mortality through risk factor analysis among initially asymptomatic patients.Results The prevalence of initially asymptomatic patients upon admission was 25.8%. The mortality rates were not different between groups (3.3% vs. 4.5%, p = .17). However, initially symptomatic patients were more likely to receive ICU care compared to initially asymptomatic patients (4.1% vs. 1.0%, p < .0001). The age-adjusted Charlson comorbidity index score (CCIS) was the most potent predictor for patient mortality in initially asymptomatic patients.Conclusions The mortality risk was not determined by the initial presence of symptom among hospitalized COVID-19 patients. The CCIS was the most potent predictors for mortality. The clinicians should predict the risk of death by evaluating age and comorbidities but not the initial presence of symptom.Key messagesThe mortality rate was not different between initially asymptomatic and symptomatic patients.Symptomatic patients were more likely to admitted to the intensive care unit.Age and comorbidities were the potent risk factors for mortality. |
| first_indexed | 2024-03-08T21:57:57Z |
| format | Article |
| id | doaj.art-4f13df2aca844de8aeb7aa59629ff1da |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T21:57:57Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-4f13df2aca844de8aeb7aa59629ff1da2023-12-19T16:46:26ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602021-01-0153135736410.1080/07853890.2021.1884744Clinical outcomes of initially asymptomatic patients with COVID-19: a Korean nationwide cohort studyHayne Cho Park0Do Hyoung Kim1Ajin Cho2Juhee Kim3Kyu-sang Yun4Jinseog Kim5Young-Ki Lee6Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, KoreaDepartment of Bigdata and Applied Statistics, Dongguk University, Gyeongju, KoreaDepartment of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, KoreaAbstractBackground This study was performed to compare severe clinical outcome between initially asymptomatic and symptomatic infections and to identify risk factors associated with high patient mortality among initially asymptomatic patients.Methods In this retrospective, nationwide cohort study, we included 5621 patients who had been discharged from isolation or died from COVID-19 by 30 April 2020. The mortality rate and admission rate to intensive care unit (ICU) were compared between initially asymptomatic and symptomatic patients. We established a prediction model for patient mortality through risk factor analysis among initially asymptomatic patients.Results The prevalence of initially asymptomatic patients upon admission was 25.8%. The mortality rates were not different between groups (3.3% vs. 4.5%, p = .17). However, initially symptomatic patients were more likely to receive ICU care compared to initially asymptomatic patients (4.1% vs. 1.0%, p < .0001). The age-adjusted Charlson comorbidity index score (CCIS) was the most potent predictor for patient mortality in initially asymptomatic patients.Conclusions The mortality risk was not determined by the initial presence of symptom among hospitalized COVID-19 patients. The CCIS was the most potent predictors for mortality. The clinicians should predict the risk of death by evaluating age and comorbidities but not the initial presence of symptom.Key messagesThe mortality rate was not different between initially asymptomatic and symptomatic patients.Symptomatic patients were more likely to admitted to the intensive care unit.Age and comorbidities were the potent risk factors for mortality.https://www.tandfonline.com/doi/10.1080/07853890.2021.1884744Asymptomatic infectionsCOVID-19mortalitycomorbidity |
| spellingShingle | Hayne Cho Park Do Hyoung Kim Ajin Cho Juhee Kim Kyu-sang Yun Jinseog Kim Young-Ki Lee Clinical outcomes of initially asymptomatic patients with COVID-19: a Korean nationwide cohort study Annals of Medicine Asymptomatic infections COVID-19 mortality comorbidity |
| title | Clinical outcomes of initially asymptomatic patients with COVID-19: a Korean nationwide cohort study |
| title_full | Clinical outcomes of initially asymptomatic patients with COVID-19: a Korean nationwide cohort study |
| title_fullStr | Clinical outcomes of initially asymptomatic patients with COVID-19: a Korean nationwide cohort study |
| title_full_unstemmed | Clinical outcomes of initially asymptomatic patients with COVID-19: a Korean nationwide cohort study |
| title_short | Clinical outcomes of initially asymptomatic patients with COVID-19: a Korean nationwide cohort study |
| title_sort | clinical outcomes of initially asymptomatic patients with covid 19 a korean nationwide cohort study |
| topic | Asymptomatic infections COVID-19 mortality comorbidity |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2021.1884744 |
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