Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors.
Vigabatrin (VGB) is a commonly prescribed antiepileptic drug designed to inhibit GABA-transaminase, effectively halting seizures. Unfortunately, VGB treatment is also associated with the highest frequencies of peripheral visual field constriction of any of the antiepileptic drugs and the mechanisms...
| Main Authors: | , , , , , , , |
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| 格式: | Article |
| 語言: | English |
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Public Library of Science (PLoS)
2012-01-01
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| 叢編: | PLoS ONE |
| 在線閱讀: | http://europepmc.org/articles/PMC3431405?pdf=render |
| _version_ | 1828931942076121088 |
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| author | Jin Yang Matthew C Naumann Yi-Ting Tsai Joaquin Tosi Deniz Erol Chyuan-Sheng Lin Richard J Davis Stephen H Tsang |
| author_facet | Jin Yang Matthew C Naumann Yi-Ting Tsai Joaquin Tosi Deniz Erol Chyuan-Sheng Lin Richard J Davis Stephen H Tsang |
| author_sort | Jin Yang |
| collection | DOAJ |
| description | Vigabatrin (VGB) is a commonly prescribed antiepileptic drug designed to inhibit GABA-transaminase, effectively halting seizures. Unfortunately, VGB treatment is also associated with the highest frequencies of peripheral visual field constriction of any of the antiepileptic drugs and the mechanisms that lead to these visual field defects are uncertain. Recent studies have demonstrated light exposure exacerbates vigabatrin-induced retinal toxicity. We further assessed this relationship by examining the effects of vigabatrin treatment on the retinal structures of mice with genetically altered photoreception. In keeping with previous studies, we detected increased toxicity in mice exposed to continuous light. To study whether cone or rod photoreceptor function was involved in the pathway to toxicity, we tested mice with mutations in the cone-specific Gnat2 or rod-specific Pde6g genes, and found the mutations significantly reduced VGB toxicity. Our results confirm light is a significant enhancer of vigabatrin toxicity and that a portion of this is mediated, directly or indirectly, by phototransduction signaling in rod and cone photoreceptors. |
| first_indexed | 2024-12-14T00:54:43Z |
| format | Article |
| id | doaj.art-4f156943f4d74f4d91d69ce3c96ccbd0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T00:54:43Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4f156943f4d74f4d91d69ce3c96ccbd02022-12-21T23:23:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e4388910.1371/journal.pone.0043889Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors.Jin YangMatthew C NaumannYi-Ting TsaiJoaquin TosiDeniz ErolChyuan-Sheng LinRichard J DavisStephen H TsangVigabatrin (VGB) is a commonly prescribed antiepileptic drug designed to inhibit GABA-transaminase, effectively halting seizures. Unfortunately, VGB treatment is also associated with the highest frequencies of peripheral visual field constriction of any of the antiepileptic drugs and the mechanisms that lead to these visual field defects are uncertain. Recent studies have demonstrated light exposure exacerbates vigabatrin-induced retinal toxicity. We further assessed this relationship by examining the effects of vigabatrin treatment on the retinal structures of mice with genetically altered photoreception. In keeping with previous studies, we detected increased toxicity in mice exposed to continuous light. To study whether cone or rod photoreceptor function was involved in the pathway to toxicity, we tested mice with mutations in the cone-specific Gnat2 or rod-specific Pde6g genes, and found the mutations significantly reduced VGB toxicity. Our results confirm light is a significant enhancer of vigabatrin toxicity and that a portion of this is mediated, directly or indirectly, by phototransduction signaling in rod and cone photoreceptors.http://europepmc.org/articles/PMC3431405?pdf=render |
| spellingShingle | Jin Yang Matthew C Naumann Yi-Ting Tsai Joaquin Tosi Deniz Erol Chyuan-Sheng Lin Richard J Davis Stephen H Tsang Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors. PLoS ONE |
| title | Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors. |
| title_full | Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors. |
| title_fullStr | Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors. |
| title_full_unstemmed | Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors. |
| title_short | Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors. |
| title_sort | vigabatrin induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors |
| url | http://europepmc.org/articles/PMC3431405?pdf=render |
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