Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors.
Vigabatrin (VGB) is a commonly prescribed antiepileptic drug designed to inhibit GABA-transaminase, effectively halting seizures. Unfortunately, VGB treatment is also associated with the highest frequencies of peripheral visual field constriction of any of the antiepileptic drugs and the mechanisms...
Main Authors: | Jin Yang, Matthew C Naumann, Yi-Ting Tsai, Joaquin Tosi, Deniz Erol, Chyuan-Sheng Lin, Richard J Davis, Stephen H Tsang |
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格式: | 文件 |
语言: | English |
出版: |
Public Library of Science (PLoS)
2012-01-01
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丛编: | PLoS ONE |
在线阅读: | http://europepmc.org/articles/PMC3431405?pdf=render |
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