| Summary: | Runoff estimations play an important role in water resource planning and management. Many accomplishments have been made in runoff estimations based on data recorded at meteorological stations; however, the advantages of the use of remotely sensed data in estimating runoff in watersheds for which data are lacking remain to be investigated. In this study, the MOD13A2 normalized difference vegetation index (NDVI), TRMM3B43 precipitation (P), MOD11A2 land–surface temperature (LST), MOD16A2 evapotranspiration (ET) and hydrological station data were used as data sources with which to estimate the monthly runoff through the application of a fully connected long short–term memory (LSTM) model in the upstream reach of the Heihe River basin in China from 2001 to 2016. The results showed that inputting multiple remote sensing parameters improved the quality of runoff estimation compared to the use of rain gauge observations; an increase in R<sup>2</sup> from 0.91 to 0.94 was observed from the implementation of this process, and Nash–Sutcliffe efficiency (NSE) showed an improvement from 0.89 to 0.93. The incorporation of rain gauge data as well as satellite data provided a slight improvement in estimating runoff with a respective R<sup>2</sup> value of 0.95 and NSE value of 0.94. This indicates that the LSTM model based on remote sensing data has great potential for runoff estimation, and data obtained by remote sensing technology provide an alternative approach for estimating runoff in areas for which available data are lacking.
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