The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose–response meta-analysis
BackgroundThe triglyceride and glucose (TyG) index is associated with the risk of nonalcoholic fatty liver disease (NAFLD), but the dose−response relationship between them is still unknown. We conducted a comprehensive meta-analysis to study the dose−response association between the TyG index and th...
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| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1043169/full |
| _version_ | 1797948172491816960 |
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| author | Qin Ling Qin Ling Jiawei Chen Jiawei Chen Xiao Liu Yi Xu Yi Xu Jianyong Ma Peng Yu Kai Zheng Fuwei Liu Jun Luo |
| author_facet | Qin Ling Qin Ling Jiawei Chen Jiawei Chen Xiao Liu Yi Xu Yi Xu Jianyong Ma Peng Yu Kai Zheng Fuwei Liu Jun Luo |
| author_sort | Qin Ling |
| collection | DOAJ |
| description | BackgroundThe triglyceride and glucose (TyG) index is associated with the risk of nonalcoholic fatty liver disease (NAFLD), but the dose−response relationship between them is still unknown. We conducted a comprehensive meta-analysis to study the dose−response association between the TyG index and the risk of NAFLD.MethodsWe systematically searched the Cochrane Library, PubMed, and Embase databases until July 2022 for relevant studies. The robust error meta-regression method was used to investigate the dose−response association between the TyG index and NAFLD. Summary relative risks (ORs) and 95% CIs were estimated by using a random-effects model.ResultsA total of 4 cohort and 8 cross-sectional studies were included, with 28,788 NAFLD cases among the 105,365 participants. A positive association for the risk of NAFLD was observed for each additional unit of the TyG index with a linear association (p=0.82), and the summary OR was 2.84 (95% CI, 2.01-4.01). In the subgroup analyses, a stronger association of the TyG index with NAFLD was shown in females than in males (men: OR=2.97, 95% CI 2.55-3.46, women: OR=4.80, 95% CI 3.90-5.90, Psubgroup<0.001).ConclusionThe TyG index may be a novel independent risk factor for NAFLD beyond traditional risk factors.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero, identifier (CRD42022347813). |
| first_indexed | 2024-04-10T21:39:08Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T21:39:08Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4f17ea8160fe4fa2936cac178da883832023-01-19T06:36:31ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-01-011310.3389/fendo.2022.10431691043169The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose–response meta-analysisQin Ling0Qin Ling1Jiawei Chen2Jiawei Chen3Xiao Liu4Yi Xu5Yi Xu6Jianyong Ma7Peng Yu8Kai Zheng9Fuwei Liu10Jun Luo11Department of Cardiology, the Affiliated Ganzhou Hospital of Nanchang University, Jiangxi, ChinaThe Second Clinical Medical College of Nanchang University, Jiangxi, ChinaDepartment of Cardiology, the Affiliated Ganzhou Hospital of Nanchang University, Jiangxi, ChinaThe Second Clinical Medical College of Nanchang University, Jiangxi, ChinaDepartment of Cardiology, the Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Cardiology, the Affiliated Ganzhou Hospital of Nanchang University, Jiangxi, ChinaThe Second Clinical Medical College of Nanchang University, Jiangxi, ChinaDepartment of Pharmacology and Systems Physiology, University of Cinnati College of Medicine, Cincinnati, OH, United StatesDepartment of Endocrine, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaMedical Care Strategic Customer Department, China Merchants Bank Shenzhen Branch, Shenzhen, ChinaDepartment of Cardiology, the Affiliated Ganzhou Hospital of Nanchang University, Jiangxi, ChinaDepartment of Cardiology, the Affiliated Ganzhou Hospital of Nanchang University, Jiangxi, ChinaBackgroundThe triglyceride and glucose (TyG) index is associated with the risk of nonalcoholic fatty liver disease (NAFLD), but the dose−response relationship between them is still unknown. We conducted a comprehensive meta-analysis to study the dose−response association between the TyG index and the risk of NAFLD.MethodsWe systematically searched the Cochrane Library, PubMed, and Embase databases until July 2022 for relevant studies. The robust error meta-regression method was used to investigate the dose−response association between the TyG index and NAFLD. Summary relative risks (ORs) and 95% CIs were estimated by using a random-effects model.ResultsA total of 4 cohort and 8 cross-sectional studies were included, with 28,788 NAFLD cases among the 105,365 participants. A positive association for the risk of NAFLD was observed for each additional unit of the TyG index with a linear association (p=0.82), and the summary OR was 2.84 (95% CI, 2.01-4.01). In the subgroup analyses, a stronger association of the TyG index with NAFLD was shown in females than in males (men: OR=2.97, 95% CI 2.55-3.46, women: OR=4.80, 95% CI 3.90-5.90, Psubgroup<0.001).ConclusionThe TyG index may be a novel independent risk factor for NAFLD beyond traditional risk factors.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero, identifier (CRD42022347813).https://www.frontiersin.org/articles/10.3389/fendo.2022.1043169/fulltriglyceride and glucose indexnonalcoholic fatty liver diseasedose-responsemeta-analysisprognosis |
| spellingShingle | Qin Ling Qin Ling Jiawei Chen Jiawei Chen Xiao Liu Yi Xu Yi Xu Jianyong Ma Peng Yu Kai Zheng Fuwei Liu Jun Luo The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose–response meta-analysis Frontiers in Endocrinology triglyceride and glucose index nonalcoholic fatty liver disease dose-response meta-analysis prognosis |
| title | The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose–response meta-analysis |
| title_full | The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose–response meta-analysis |
| title_fullStr | The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose–response meta-analysis |
| title_full_unstemmed | The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose–response meta-analysis |
| title_short | The triglyceride and glucose index and risk of nonalcoholic fatty liver disease: A dose–response meta-analysis |
| title_sort | triglyceride and glucose index and risk of nonalcoholic fatty liver disease a dose response meta analysis |
| topic | triglyceride and glucose index nonalcoholic fatty liver disease dose-response meta-analysis prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1043169/full |
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