Extracellular vesicles as modulators of glioblastoma progression and tumor microenvironment
Glioblastoma is the most aggressive brain tumor with extremely poor prognosis in adults. Routine treatments include surgery, chemotherapy, and radiotherapy; however, these may lead to rapid relapse and development of therapy-resistant tumor. Glioblastoma cells are known to communicate with macrophag...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Pathology and Oncology Research |
| Subjects: | |
| Online Access: | https://www.por-journal.com/articles/10.3389/pore.2024.1611549/full |
| _version_ | 1827293145772064768 |
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| author | Jie Dai Yong Jiang Haoyue Hu Shuang Zhang Yue Chen |
| author_facet | Jie Dai Yong Jiang Haoyue Hu Shuang Zhang Yue Chen |
| author_sort | Jie Dai |
| collection | DOAJ |
| description | Glioblastoma is the most aggressive brain tumor with extremely poor prognosis in adults. Routine treatments include surgery, chemotherapy, and radiotherapy; however, these may lead to rapid relapse and development of therapy-resistant tumor. Glioblastoma cells are known to communicate with macrophages, microglia, endothelial cells, astrocytes, and immune cells in the tumor microenvironment (TME) to promote tumor preservation. It was recently demonstrated that Glioblastoma-derived extracellular vesicles (EVs) participate in bidirectional intercellular communication in the TME. Apart from promoting glioblastoma cell proliferation, migration, and angiogenesis, EVs and their cargos (primarily proteins and miRNAs) can act as biomarkers for tumor diagnosis and prognosis. Furthermore, they can be used as therapeutic tools. In this review, the mechanisms of Glioblastoma-EVs biogenesis and intercellular communication with TME have been summarized. Moreover, there is discussion surrounding EVs as novel diagnostic structures and therapeutic tools for glioblastoma. Finally, unclear questions that require future investigation have been reviewed. |
| first_indexed | 2024-04-24T13:20:14Z |
| format | Article |
| id | doaj.art-4f18c0af09df453dbf30a493b64a4a71 |
| institution | Directory Open Access Journal |
| issn | 1532-2807 |
| language | English |
| last_indexed | 2024-04-24T13:20:14Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Pathology and Oncology Research |
| spelling | doaj.art-4f18c0af09df453dbf30a493b64a4a712024-04-04T16:14:16ZengFrontiers Media S.A.Pathology and Oncology Research1532-28072024-02-013010.3389/pore.2024.16115491611549Extracellular vesicles as modulators of glioblastoma progression and tumor microenvironmentJie Dai0Yong Jiang1Haoyue Hu2Shuang Zhang3Yue Chen4Department of Pathology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Neurosurgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Medical Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDepartment of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaGlioblastoma is the most aggressive brain tumor with extremely poor prognosis in adults. Routine treatments include surgery, chemotherapy, and radiotherapy; however, these may lead to rapid relapse and development of therapy-resistant tumor. Glioblastoma cells are known to communicate with macrophages, microglia, endothelial cells, astrocytes, and immune cells in the tumor microenvironment (TME) to promote tumor preservation. It was recently demonstrated that Glioblastoma-derived extracellular vesicles (EVs) participate in bidirectional intercellular communication in the TME. Apart from promoting glioblastoma cell proliferation, migration, and angiogenesis, EVs and their cargos (primarily proteins and miRNAs) can act as biomarkers for tumor diagnosis and prognosis. Furthermore, they can be used as therapeutic tools. In this review, the mechanisms of Glioblastoma-EVs biogenesis and intercellular communication with TME have been summarized. Moreover, there is discussion surrounding EVs as novel diagnostic structures and therapeutic tools for glioblastoma. Finally, unclear questions that require future investigation have been reviewed.https://www.por-journal.com/articles/10.3389/pore.2024.1611549/fullextracellular vesiclestumor microenvironmentglioblastomaexosomesmicrovesicles |
| spellingShingle | Jie Dai Yong Jiang Haoyue Hu Shuang Zhang Yue Chen Extracellular vesicles as modulators of glioblastoma progression and tumor microenvironment Pathology and Oncology Research extracellular vesicles tumor microenvironment glioblastoma exosomes microvesicles |
| title | Extracellular vesicles as modulators of glioblastoma progression and tumor microenvironment |
| title_full | Extracellular vesicles as modulators of glioblastoma progression and tumor microenvironment |
| title_fullStr | Extracellular vesicles as modulators of glioblastoma progression and tumor microenvironment |
| title_full_unstemmed | Extracellular vesicles as modulators of glioblastoma progression and tumor microenvironment |
| title_short | Extracellular vesicles as modulators of glioblastoma progression and tumor microenvironment |
| title_sort | extracellular vesicles as modulators of glioblastoma progression and tumor microenvironment |
| topic | extracellular vesicles tumor microenvironment glioblastoma exosomes microvesicles |
| url | https://www.por-journal.com/articles/10.3389/pore.2024.1611549/full |
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