Ultrastructural liver changes in the experimental thyrotoxicosis
Aim of the study is to evaluate ultrastructural changes of rat liver in experimental thyrotoxicosis. For the study, 36 male rats have been utilized, weighing approximately 150-190 g, which were divided into three groups: the first, control group (12 animals) was composed of healthy rats that receiv...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2017-09-01
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| Series: | Polish Journal of Pathology |
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| Online Access: | https://www.termedia.pl/Ultrastructural-liver-changes-in-the-experimental-thyrotoxicosis,55,30489,1,1.html |
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| author | Nadiya Vasylivna Pasyechko Iryna Ihorivna Kuleshko Veronika Mykolaiivna Kulchinska Liudmyla Valeriivna Naumova Iryna Volodymyrivna Smachylo Anzhela Olehivna Bob Liudmyla Volodymyrivna Radetska Mykhailo Yevhenovych Havryliuk Olha Mykolaiivna Sopel Liudmyla Petrivna Mazur |
| author_facet | Nadiya Vasylivna Pasyechko Iryna Ihorivna Kuleshko Veronika Mykolaiivna Kulchinska Liudmyla Valeriivna Naumova Iryna Volodymyrivna Smachylo Anzhela Olehivna Bob Liudmyla Volodymyrivna Radetska Mykhailo Yevhenovych Havryliuk Olha Mykolaiivna Sopel Liudmyla Petrivna Mazur |
| author_sort | Nadiya Vasylivna Pasyechko |
| collection | DOAJ |
| description | Aim of the study is to evaluate ultrastructural changes of rat liver in experimental thyrotoxicosis.
For the study, 36 male rats have been utilized, weighing approximately 150-190 g, which were divided into three groups: the first, control group (12 animals) was composed of healthy rats that received intragastric sodium chloride 0.9% solution, the second group (12 animals) – animals with experimental thyrotoxicosis, which received intragastric solution of L-thyroxine at the rate of 200 μg/kg for 2 weeks, and the third group (12 animals) – rats with experimental thyrotoxicosis, which received intragastric solution of L-thyroxine at the rate of 200 μg/kg for 4 weeks. For electron-microscopic studies small pieces of liver tissue were taken at the end of the 2nd and 4th weeks of the experiment. The material was studied and documented in electron micrographs by using a TEM-125K electron microscope.
In experiment in white male rats the electron-microscopic state of the liver in thyrotoxicosis has been studied. It has been established that thyrotoxicosis is accompanied by the significant changes of the hepatocytes ultrastructure, blood and bile capillaries. Experimental thyrotoxicosis causes significant damage of the liver plasma membranes and intracellular structural components of hepatocytes and endothelial cells.
In experimental thyrotoxicosis, on the background of microcirculatory disorders, significant damage of plasmatic and intracellular organoid membranes of hepatocytes in the liver develops, which has an adverse effect on the functionality of the organ. The found ultrastructural changes are aggravated depending on the duration of thyrotoxicosis. |
| first_indexed | 2024-12-10T08:01:40Z |
| format | Article |
| id | doaj.art-4f1ad2741c3b4ffc87f0d22a4859d841 |
| institution | Directory Open Access Journal |
| issn | 1233-9687 2084-9869 |
| language | English |
| last_indexed | 2024-12-10T08:01:40Z |
| publishDate | 2017-09-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Pathology |
| spelling | doaj.art-4f1ad2741c3b4ffc87f0d22a4859d8412022-12-22T01:56:46ZengTermedia Publishing HousePolish Journal of Pathology1233-96872084-98692017-09-0168214414710.5114/pjp.2017.6969030489Ultrastructural liver changes in the experimental thyrotoxicosisNadiya Vasylivna PasyechkoIryna Ihorivna KuleshkoVeronika Mykolaiivna KulchinskaLiudmyla Valeriivna NaumovaIryna Volodymyrivna SmachyloAnzhela Olehivna BobLiudmyla Volodymyrivna RadetskaMykhailo Yevhenovych HavryliukOlha Mykolaiivna SopelLiudmyla Petrivna MazurAim of the study is to evaluate ultrastructural changes of rat liver in experimental thyrotoxicosis. For the study, 36 male rats have been utilized, weighing approximately 150-190 g, which were divided into three groups: the first, control group (12 animals) was composed of healthy rats that received intragastric sodium chloride 0.9% solution, the second group (12 animals) – animals with experimental thyrotoxicosis, which received intragastric solution of L-thyroxine at the rate of 200 μg/kg for 2 weeks, and the third group (12 animals) – rats with experimental thyrotoxicosis, which received intragastric solution of L-thyroxine at the rate of 200 μg/kg for 4 weeks. For electron-microscopic studies small pieces of liver tissue were taken at the end of the 2nd and 4th weeks of the experiment. The material was studied and documented in electron micrographs by using a TEM-125K electron microscope. In experiment in white male rats the electron-microscopic state of the liver in thyrotoxicosis has been studied. It has been established that thyrotoxicosis is accompanied by the significant changes of the hepatocytes ultrastructure, blood and bile capillaries. Experimental thyrotoxicosis causes significant damage of the liver plasma membranes and intracellular structural components of hepatocytes and endothelial cells. In experimental thyrotoxicosis, on the background of microcirculatory disorders, significant damage of plasmatic and intracellular organoid membranes of hepatocytes in the liver develops, which has an adverse effect on the functionality of the organ. The found ultrastructural changes are aggravated depending on the duration of thyrotoxicosis.https://www.termedia.pl/Ultrastructural-liver-changes-in-the-experimental-thyrotoxicosis,55,30489,1,1.htmlthyrotoxicosis liver ultrastructural changes rat |
| spellingShingle | Nadiya Vasylivna Pasyechko Iryna Ihorivna Kuleshko Veronika Mykolaiivna Kulchinska Liudmyla Valeriivna Naumova Iryna Volodymyrivna Smachylo Anzhela Olehivna Bob Liudmyla Volodymyrivna Radetska Mykhailo Yevhenovych Havryliuk Olha Mykolaiivna Sopel Liudmyla Petrivna Mazur Ultrastructural liver changes in the experimental thyrotoxicosis Polish Journal of Pathology thyrotoxicosis liver ultrastructural changes rat |
| title | Ultrastructural liver changes in the experimental thyrotoxicosis |
| title_full | Ultrastructural liver changes in the experimental thyrotoxicosis |
| title_fullStr | Ultrastructural liver changes in the experimental thyrotoxicosis |
| title_full_unstemmed | Ultrastructural liver changes in the experimental thyrotoxicosis |
| title_short | Ultrastructural liver changes in the experimental thyrotoxicosis |
| title_sort | ultrastructural liver changes in the experimental thyrotoxicosis |
| topic | thyrotoxicosis liver ultrastructural changes rat |
| url | https://www.termedia.pl/Ultrastructural-liver-changes-in-the-experimental-thyrotoxicosis,55,30489,1,1.html |
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