Net positive charge of HIV-1 CRF01_AE V3 sequence regulates viral sensitivity to humoral immunity.

Net positive charge of HIV-1 CRF01_AE V3 sequence regulates viral sensitivity to humoral immunity.

The third variable region (V3) of the human immunodeficiency virus type 1 (HIV-1) envelope gp120 subunit participates in determination of viral infection coreceptor tropism and host humoral immune responses. Positive charge of the V3 plays a key role in determining viral coreceptor tropism. Here, we...

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Main Authors: Satoshi Naganawa, Masaru Yokoyama, Teiichiro Shiino, Takeyuki Suzuki, Yoshiaki Ishigatsubo, Atsuhisa Ueda, Akira Shirai, Mitsuhiro Takeno, Satoshi Hayakawa, Shigehiro Sato, Osamu Tochikubo, Shingo Kiyoura, Kaori Sawada, Takashi Ikegami, Tadahito Kanda, Katsuhiko Kitamura, Hironori Sato
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2527523?pdf=render

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