Single-cell analysis of thymocyte differentiation: identification of transcription factor interactions and a major stochastic component in αβ-lineage commitment.

Single-cell analysis of thymocyte differentiation: identification of transcription factor interactions and a major stochastic component in αβ-lineage commitment.

T cell commitment and αβ/γδ lineage specification in the thymus involves interactions between many different genes. Characterization of these interactions thus requires a multiparameter analysis of individual thymocytes. We developed two efficient single-cell methods: (i) the quantitative evaluation...

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Bibliographic Details
Main Authors: Amine Boudil, Lamia Skhiri, Serge Candéias, Valérie Pasqualetto, Agnès Legrand, Marie Bedora-Faure, Laetitia Gautreau-Rolland, Benedita Rocha, Sophie Ezine
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3787938?pdf=render

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