Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India
Abstract Objective Chronic obstructive airway disease (COPD) is characterized by airflow limitation due to airway and/or alveolar abnormalities with significant extra‐pulmonary manifestations. Bone health impairment is an extra‐pulmonary complication of COPD which is less well studied in India. More...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Aging Medicine |
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| Online Access: | https://doi.org/10.1002/agm2.12239 |
| _version_ | 1811154964126367744 |
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| author | Mohammad Sadiq Jeeyavudeen Samuel George Hansdek Nihal Thomas Thangakunam Balamugesh Mahasampath Gowri Thomas V. Paul |
| author_facet | Mohammad Sadiq Jeeyavudeen Samuel George Hansdek Nihal Thomas Thangakunam Balamugesh Mahasampath Gowri Thomas V. Paul |
| author_sort | Mohammad Sadiq Jeeyavudeen |
| collection | DOAJ |
| description | Abstract Objective Chronic obstructive airway disease (COPD) is characterized by airflow limitation due to airway and/or alveolar abnormalities with significant extra‐pulmonary manifestations. Bone health impairment is an extra‐pulmonary complication of COPD which is less well studied in India. Moreover, it can contribute to significant morbidity and mortality. Hence, we aim to estimate the prevalence of osteoporosis and metabolic parameters of adverse bone health in patients with COPD. Methods In this case control study, male subjects aged 40–70 years with COPD attending the respiratory outpatient clinic in a tertiary care hospital were recruited over a period of 2 years and the control population were derived from the historical cohort who were apparently healthy with no obvious diseases. Metabolic parameters of bone health measured from fasting blood samples were calcium, albumin, alkaline phosphatase, phosphorous, parathormone, creatinine, 25‐hydroxy vitamin D, and testosterone. Bone mineral density (BMD) was estimated using DXA scan and the World Health Organization (WHO) criteria was used to categorize into osteoporosis, osteopenia, and normal BMD based on the T‐score at femoral neck, lumbar spine and distal forearm. Pulmonary function tests and 6 minute walk test were performed if they had not been done in the previous 3 months. The associations of COPD with osteoporosis were analyzed using linear regression analysis and effect size are presented as beta with 95% confidence interval. Results Of the 67 participants with COPD enrolled in the study, osteoporosis was present in 61% (41/67) and osteopenia in an additional 33% (22/67) of the cases, which was higher when compared to the control population (osteoporosis 20% [50/252] and osteopenia 58% [146/252]). In regression modeling, there was a trend toward adverse bone health with advanced age, low body mass index, low forced expiratory volume in 1 second and testosterone deficiency in COPD. Conclusion Individuals with COPD have a substantially higher prevalence of osteoporosis and osteopenia, up to almost twice that of the general population, with a significant number demonstrating at least one parameter of adverse metabolic bone health on assessment. Hence, bone health assessment should be a part of comprehensive COPD care to prevent adverse consequences due to poor bone health. |
| first_indexed | 2024-04-10T04:26:00Z |
| format | Article |
| id | doaj.art-4f1f50d28b8f4701aee8c2f4104eed30 |
| institution | Directory Open Access Journal |
| issn | 2475-0360 |
| language | English |
| last_indexed | 2024-04-10T04:26:00Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aging Medicine |
| spelling | doaj.art-4f1f50d28b8f4701aee8c2f4104eed302023-03-10T14:20:24ZengWileyAging Medicine2475-03602023-03-0161637010.1002/agm2.12239Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from IndiaMohammad Sadiq Jeeyavudeen0Samuel George Hansdek1Nihal Thomas2Thangakunam Balamugesh3Mahasampath Gowri4Thomas V. Paul5Department of Endocrinology and Metabolism University Hospitals of Edinburgh Edinburgh UKDepartment of General Medicine Christian Medical College and Hospital Vellore IndiaDepartment of Endocrinology, Diabetes, and Metabolism Christian Medical College and Hospital Vellore IndiaDepartment of Pulmonary Medicine Christian Medical College and Hospital Vellore IndiaDepartment of Biostatistics Christian Medical College and Hospital Vellore IndiaDepartment of Endocrinology, Diabetes, and Metabolism Christian Medical College and Hospital Vellore IndiaAbstract Objective Chronic obstructive airway disease (COPD) is characterized by airflow limitation due to airway and/or alveolar abnormalities with significant extra‐pulmonary manifestations. Bone health impairment is an extra‐pulmonary complication of COPD which is less well studied in India. Moreover, it can contribute to significant morbidity and mortality. Hence, we aim to estimate the prevalence of osteoporosis and metabolic parameters of adverse bone health in patients with COPD. Methods In this case control study, male subjects aged 40–70 years with COPD attending the respiratory outpatient clinic in a tertiary care hospital were recruited over a period of 2 years and the control population were derived from the historical cohort who were apparently healthy with no obvious diseases. Metabolic parameters of bone health measured from fasting blood samples were calcium, albumin, alkaline phosphatase, phosphorous, parathormone, creatinine, 25‐hydroxy vitamin D, and testosterone. Bone mineral density (BMD) was estimated using DXA scan and the World Health Organization (WHO) criteria was used to categorize into osteoporosis, osteopenia, and normal BMD based on the T‐score at femoral neck, lumbar spine and distal forearm. Pulmonary function tests and 6 minute walk test were performed if they had not been done in the previous 3 months. The associations of COPD with osteoporosis were analyzed using linear regression analysis and effect size are presented as beta with 95% confidence interval. Results Of the 67 participants with COPD enrolled in the study, osteoporosis was present in 61% (41/67) and osteopenia in an additional 33% (22/67) of the cases, which was higher when compared to the control population (osteoporosis 20% [50/252] and osteopenia 58% [146/252]). In regression modeling, there was a trend toward adverse bone health with advanced age, low body mass index, low forced expiratory volume in 1 second and testosterone deficiency in COPD. Conclusion Individuals with COPD have a substantially higher prevalence of osteoporosis and osteopenia, up to almost twice that of the general population, with a significant number demonstrating at least one parameter of adverse metabolic bone health on assessment. Hence, bone health assessment should be a part of comprehensive COPD care to prevent adverse consequences due to poor bone health.https://doi.org/10.1002/agm2.12239COPDosteopeniaosteoporosisvitamin D deficiency |
| spellingShingle | Mohammad Sadiq Jeeyavudeen Samuel George Hansdek Nihal Thomas Thangakunam Balamugesh Mahasampath Gowri Thomas V. Paul Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India Aging Medicine COPD osteopenia osteoporosis vitamin D deficiency |
| title | Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India |
| title_full | Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India |
| title_fullStr | Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India |
| title_full_unstemmed | Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India |
| title_short | Bone health in ambulatory male patients with chronic obstructive airway disease – A case control study from India |
| title_sort | bone health in ambulatory male patients with chronic obstructive airway disease a case control study from india |
| topic | COPD osteopenia osteoporosis vitamin D deficiency |
| url | https://doi.org/10.1002/agm2.12239 |
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