Correlation and influencing factors analysis of colorectal polyps with Helicobacter pylori Infection and p-S6K1 expression
Abstract Objective To investigate the correlation between colorectal polyps (CRP) and Helicobacter pylori (H. pylori) infection, and the correlation between CRP and the expression of phosphorylated ribosomal protein S6 kinase (p-S6K1). Besides, its related influencing factors were determined in the...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-023-08791-y |
| _version_ | 1827724400909090816 |
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| author | Zeming Jia Xiaoping Wan |
| author_facet | Zeming Jia Xiaoping Wan |
| author_sort | Zeming Jia |
| collection | DOAJ |
| description | Abstract Objective To investigate the correlation between colorectal polyps (CRP) and Helicobacter pylori (H. pylori) infection, and the correlation between CRP and the expression of phosphorylated ribosomal protein S6 kinase (p-S6K1). Besides, its related influencing factors were determined in the present study. Methods A total of 191 subjects who underwent colonoscopy in our hospital from January 2020 to February 2022 were selected for this study. Among them, 141 patients were diagnosed with CRP, and the other 50 subjects were no significant colorectal abnormalities. 141 CRP patients were divided into H. pylori-positive group (n = 89) and H. pylori-negative group (n = 52) according to the results of the H. pylori test. The expression of p-S6K1 in CRP tissue was detected. The relationship between the p-S6K1 expression and the clinicopathological characteristics of CRP patients was analyzed. The logistic analysis of factors influencing the occurrence of CRP was performed. Results There were significant differences in pathological type, site of disease, the number and size of polyps between the H. pylori negative group and the H. pylori positive group (P < 0.001, P = 0.037, P = 0.042 and P = 0.039). The percentage of the p-S6K1 positive expression in polyp tissues was higher than that in normal tissue and parapolyp tissues (P < 0.001). The p-S6K1 negative group showed significant difference in the number and pathological type of polyps and the presence or absence of a pedicle as compared with the p-S6K1 positive group (P = 0.006, P < 0.001 and P = 0.012). Logistic multifactor analysis showed that BMI, H. pylori infection, smoking history, ApoB, Lp(a) and the p-S6K1 positive expression were all risk factors for the development of CRP (P = 0.025, P = 0.020, P = 0.010, P = 0.005, P = 0.043 and P < 0.001). Conclusion H. pylori infection was closely related to the pathological type, location, and the number and size of CRP. p-S6K1 was highly expressed in CRP, and was positively related to the number, the pathological type and pedicle of polyps. H. pylori infection and the positive p-S6K1 expression were independent risk factors for CRP. By exploring the association between H. pylori infection as well as p-S6K1 and CRP, it is hoped that it will help to formulate a more rigorous colorectal cancer screening program for H. pylori-positive individuals, and at the same time find a new direction for the prevention of CRP and colorectal cancer, and provide some help for future research. |
| first_indexed | 2024-03-10T22:14:11Z |
| format | Article |
| id | doaj.art-4f202040ef494299b11f34a6fc342ed0 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-10T22:14:11Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-4f202040ef494299b11f34a6fc342ed02023-11-19T12:29:20ZengBMCBMC Infectious Diseases1471-23342023-11-012311810.1186/s12879-023-08791-yCorrelation and influencing factors analysis of colorectal polyps with Helicobacter pylori Infection and p-S6K1 expressionZeming Jia0Xiaoping Wan1Department of General Surgery, Xiangya Hospital, Central South UniversityDepartment of General Surgery, Xiangya Hospital, Central South UniversityAbstract Objective To investigate the correlation between colorectal polyps (CRP) and Helicobacter pylori (H. pylori) infection, and the correlation between CRP and the expression of phosphorylated ribosomal protein S6 kinase (p-S6K1). Besides, its related influencing factors were determined in the present study. Methods A total of 191 subjects who underwent colonoscopy in our hospital from January 2020 to February 2022 were selected for this study. Among them, 141 patients were diagnosed with CRP, and the other 50 subjects were no significant colorectal abnormalities. 141 CRP patients were divided into H. pylori-positive group (n = 89) and H. pylori-negative group (n = 52) according to the results of the H. pylori test. The expression of p-S6K1 in CRP tissue was detected. The relationship between the p-S6K1 expression and the clinicopathological characteristics of CRP patients was analyzed. The logistic analysis of factors influencing the occurrence of CRP was performed. Results There were significant differences in pathological type, site of disease, the number and size of polyps between the H. pylori negative group and the H. pylori positive group (P < 0.001, P = 0.037, P = 0.042 and P = 0.039). The percentage of the p-S6K1 positive expression in polyp tissues was higher than that in normal tissue and parapolyp tissues (P < 0.001). The p-S6K1 negative group showed significant difference in the number and pathological type of polyps and the presence or absence of a pedicle as compared with the p-S6K1 positive group (P = 0.006, P < 0.001 and P = 0.012). Logistic multifactor analysis showed that BMI, H. pylori infection, smoking history, ApoB, Lp(a) and the p-S6K1 positive expression were all risk factors for the development of CRP (P = 0.025, P = 0.020, P = 0.010, P = 0.005, P = 0.043 and P < 0.001). Conclusion H. pylori infection was closely related to the pathological type, location, and the number and size of CRP. p-S6K1 was highly expressed in CRP, and was positively related to the number, the pathological type and pedicle of polyps. H. pylori infection and the positive p-S6K1 expression were independent risk factors for CRP. By exploring the association between H. pylori infection as well as p-S6K1 and CRP, it is hoped that it will help to formulate a more rigorous colorectal cancer screening program for H. pylori-positive individuals, and at the same time find a new direction for the prevention of CRP and colorectal cancer, and provide some help for future research.https://doi.org/10.1186/s12879-023-08791-yColorectal polypsHelicobacter pylori InfectionCorrelationp-S6K1Clinical significance |
| spellingShingle | Zeming Jia Xiaoping Wan Correlation and influencing factors analysis of colorectal polyps with Helicobacter pylori Infection and p-S6K1 expression BMC Infectious Diseases Colorectal polyps Helicobacter pylori Infection Correlation p-S6K1 Clinical significance |
| title | Correlation and influencing factors analysis of colorectal polyps with Helicobacter pylori Infection and p-S6K1 expression |
| title_full | Correlation and influencing factors analysis of colorectal polyps with Helicobacter pylori Infection and p-S6K1 expression |
| title_fullStr | Correlation and influencing factors analysis of colorectal polyps with Helicobacter pylori Infection and p-S6K1 expression |
| title_full_unstemmed | Correlation and influencing factors analysis of colorectal polyps with Helicobacter pylori Infection and p-S6K1 expression |
| title_short | Correlation and influencing factors analysis of colorectal polyps with Helicobacter pylori Infection and p-S6K1 expression |
| title_sort | correlation and influencing factors analysis of colorectal polyps with helicobacter pylori infection and p s6k1 expression |
| topic | Colorectal polyps Helicobacter pylori Infection Correlation p-S6K1 Clinical significance |
| url | https://doi.org/10.1186/s12879-023-08791-y |
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