Hepatitis B Virus-Associated Hepatocellular Carcinoma
Hepatitis B virus (HBV) is DNA-based virus, member of the Hepadnaviridae family, which can cause liver disease and increased risk of hepatocellular carcinoma (HCC) in infected individuals, replicating within the hepatocytes and interacting with several cellular proteins. Chronic hepatitis B can prog...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/5/986 |
| _version_ | 1827665889783185408 |
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| author | Giacomo Emanuele Maria Rizzo Giuseppe Cabibbo Antonio Craxì |
| author_facet | Giacomo Emanuele Maria Rizzo Giuseppe Cabibbo Antonio Craxì |
| author_sort | Giacomo Emanuele Maria Rizzo |
| collection | DOAJ |
| description | Hepatitis B virus (HBV) is DNA-based virus, member of the Hepadnaviridae family, which can cause liver disease and increased risk of hepatocellular carcinoma (HCC) in infected individuals, replicating within the hepatocytes and interacting with several cellular proteins. Chronic hepatitis B can progressively lead to liver cirrhosis, which is an independent risk factor for HCC. Complications as liver decompensation or HCC impact the survival of HBV patients and concurrent HDV infection worsens the disease. The available data provide evidence that HBV infection is associated with the risk of developing HCC with or without an underlying liver cirrhosis, due to various direct and indirect mechanisms promoting hepatocarcinogenesis. The molecular profile of HBV-HCC is extensively and continuously under study, and it is the result of altered molecular pathways, which modify the microenvironment and lead to DNA damage. HBV produces the protein HBx, which has a central role in the oncogenetic process. Furthermore, the molecular profile of HBV-HCC was recently discerned from that of HDV-HCC, despite the obligatory dependence of HDV on HBV. Proper management of the underlying HBV-related liver disease is fundamental, including HCC surveillance, viral suppression, and application of adequate predictive models. When HBV-HCC occurs, liver function and HCC characteristics guide the physician among treatment strategies but always considering the viral etiology in the treatment choice. |
| first_indexed | 2024-03-10T01:36:21Z |
| format | Article |
| id | doaj.art-4f22b18b8686429ab9767f4a7346dfcf |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T01:36:21Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-4f22b18b8686429ab9767f4a7346dfcf2023-11-23T13:31:23ZengMDPI AGViruses1999-49152022-05-0114598610.3390/v14050986Hepatitis B Virus-Associated Hepatocellular CarcinomaGiacomo Emanuele Maria Rizzo0Giuseppe Cabibbo1Antonio Craxì2Section of Gastroenterology & Hepatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, 90127 Palermo, ItalySection of Gastroenterology & Hepatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, 90127 Palermo, ItalySection of Gastroenterology & Hepatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo, 90127 Palermo, ItalyHepatitis B virus (HBV) is DNA-based virus, member of the Hepadnaviridae family, which can cause liver disease and increased risk of hepatocellular carcinoma (HCC) in infected individuals, replicating within the hepatocytes and interacting with several cellular proteins. Chronic hepatitis B can progressively lead to liver cirrhosis, which is an independent risk factor for HCC. Complications as liver decompensation or HCC impact the survival of HBV patients and concurrent HDV infection worsens the disease. The available data provide evidence that HBV infection is associated with the risk of developing HCC with or without an underlying liver cirrhosis, due to various direct and indirect mechanisms promoting hepatocarcinogenesis. The molecular profile of HBV-HCC is extensively and continuously under study, and it is the result of altered molecular pathways, which modify the microenvironment and lead to DNA damage. HBV produces the protein HBx, which has a central role in the oncogenetic process. Furthermore, the molecular profile of HBV-HCC was recently discerned from that of HDV-HCC, despite the obligatory dependence of HDV on HBV. Proper management of the underlying HBV-related liver disease is fundamental, including HCC surveillance, viral suppression, and application of adequate predictive models. When HBV-HCC occurs, liver function and HCC characteristics guide the physician among treatment strategies but always considering the viral etiology in the treatment choice.https://www.mdpi.com/1999-4915/14/5/986hepatitis B virushepatitis Bhepatitis B chronic hepatitishepatocellular carcinomahepatitis D virus |
| spellingShingle | Giacomo Emanuele Maria Rizzo Giuseppe Cabibbo Antonio Craxì Hepatitis B Virus-Associated Hepatocellular Carcinoma Viruses hepatitis B virus hepatitis B hepatitis B chronic hepatitis hepatocellular carcinoma hepatitis D virus |
| title | Hepatitis B Virus-Associated Hepatocellular Carcinoma |
| title_full | Hepatitis B Virus-Associated Hepatocellular Carcinoma |
| title_fullStr | Hepatitis B Virus-Associated Hepatocellular Carcinoma |
| title_full_unstemmed | Hepatitis B Virus-Associated Hepatocellular Carcinoma |
| title_short | Hepatitis B Virus-Associated Hepatocellular Carcinoma |
| title_sort | hepatitis b virus associated hepatocellular carcinoma |
| topic | hepatitis B virus hepatitis B hepatitis B chronic hepatitis hepatocellular carcinoma hepatitis D virus |
| url | https://www.mdpi.com/1999-4915/14/5/986 |
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