Neutrophil to lymphocyte ratio predicts early growth of traumatic intracerebral haemorrhage
Abstract Objective The neutrophil to lymphocyte ratio (NLR) has been proposed to capture the inflammatory status of patients with various conditions involving the brain. This retrospective study aimed to explore the association between the NLR and the early growth of traumatic intracerebral haemorrh...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51409 |
| _version_ | 1819140523480317952 |
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| author | Dongzhou Zhuang Jiangtao Sheng Guoyi Peng Tian Li Shirong Cai Faxiu Din Lianjie Li Mindong Huang Fei Tian Kangsheng Li Shousen Wang Weiqiang Chen |
| author_facet | Dongzhou Zhuang Jiangtao Sheng Guoyi Peng Tian Li Shirong Cai Faxiu Din Lianjie Li Mindong Huang Fei Tian Kangsheng Li Shousen Wang Weiqiang Chen |
| author_sort | Dongzhou Zhuang |
| collection | DOAJ |
| description | Abstract Objective The neutrophil to lymphocyte ratio (NLR) has been proposed to capture the inflammatory status of patients with various conditions involving the brain. This retrospective study aimed to explore the association between the NLR and the early growth of traumatic intracerebral haemorrhage (tICH) in patients with traumatic brain injury (TBI). Methods A multicentre, observational cohort study was conducted. Patients with cerebral contusion undergoing baseline computed tomography for haematoma volume analysis within 6 h after primary injury and follow‐up visits within 48 h were included. Routine blood tests were performed upon admission, and early growth of tICH was assessed. Prediction accuracies of the NLR for the early growth of tICH and subsequent surgical intervention in patients were analysed. Results There were a total of 1077 patients who met the criteria included in the study cohort. Univariate analysis results showed that multiple risk factors were associated with the early growth of tICH and included in the following multivariate analysis models. The multivariate logistic regression analysis results revealed that the NLR was highly associated with the early growth of tICH (p < 0.001) while considering other risk factors in the same model. The prediction accuracy of the NLR for the early growth of tICH in patients is 82%. Interpretation The NLR is easily calculated and might predict the early growth of tICH for patients suffering from TBI. |
| first_indexed | 2024-12-22T11:39:55Z |
| format | Article |
| id | doaj.art-4f251ac8d398440f9881bbb49ad2380b |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-22T11:39:55Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-4f251ac8d398440f9881bbb49ad2380b2022-12-21T18:27:18ZengWileyAnnals of Clinical and Translational Neurology2328-95032021-08-01881601160910.1002/acn3.51409Neutrophil to lymphocyte ratio predicts early growth of traumatic intracerebral haemorrhageDongzhou Zhuang0Jiangtao Sheng1Guoyi Peng2Tian Li3Shirong Cai4Faxiu Din5Lianjie Li6Mindong Huang7Fei Tian8Kangsheng Li9Shousen Wang10Weiqiang Chen11Department of Neurosurgery First Affiliated Hospital Shantou University Medical College 57 Changping Road Shantou Guangdong 515000 ChinaDepartment of Microbiology and Immunology & Key Immunopathology Laboratory of Guangdong Province Shantou University Medical College 22 Xinling Road Shantou Guangdong 515000 ChinaDepartment of Neurosurgery First Affiliated Hospital Shantou University Medical College 57 Changping Road Shantou Guangdong 515000 ChinaDepartment of Microbiology and Immunology & Key Immunopathology Laboratory of Guangdong Province Shantou University Medical College 22 Xinling Road Shantou Guangdong 515000 ChinaDepartment of Neurosurgery First Affiliated Hospital Shantou University Medical College 57 Changping Road Shantou Guangdong 515000 ChinaDepartment of Neurosurgery First Affiliated Hospital Shantou University Medical College 57 Changping Road Shantou Guangdong 515000 ChinaDepartment of Neurosurgery Fuzhou General Hospital of Xiamen University Fuzhou 350025 ChinaDepartment of Neurosurgery Jieyang People’s Hospital 107 Tianfu Road Jieyang ChinaDepartment of Neurosurgery The Second Affiliated Hospital of Shantou University Medical College Dongxiabei Road Shantou Guangdong 515000 ChinaDepartment of Microbiology and Immunology & Key Immunopathology Laboratory of Guangdong Province Shantou University Medical College 22 Xinling Road Shantou Guangdong 515000 ChinaDepartment of Neurosurgery Fuzhou General Hospital of Xiamen University Fuzhou 350025 ChinaDepartment of Neurosurgery First Affiliated Hospital Shantou University Medical College 57 Changping Road Shantou Guangdong 515000 ChinaAbstract Objective The neutrophil to lymphocyte ratio (NLR) has been proposed to capture the inflammatory status of patients with various conditions involving the brain. This retrospective study aimed to explore the association between the NLR and the early growth of traumatic intracerebral haemorrhage (tICH) in patients with traumatic brain injury (TBI). Methods A multicentre, observational cohort study was conducted. Patients with cerebral contusion undergoing baseline computed tomography for haematoma volume analysis within 6 h after primary injury and follow‐up visits within 48 h were included. Routine blood tests were performed upon admission, and early growth of tICH was assessed. Prediction accuracies of the NLR for the early growth of tICH and subsequent surgical intervention in patients were analysed. Results There were a total of 1077 patients who met the criteria included in the study cohort. Univariate analysis results showed that multiple risk factors were associated with the early growth of tICH and included in the following multivariate analysis models. The multivariate logistic regression analysis results revealed that the NLR was highly associated with the early growth of tICH (p < 0.001) while considering other risk factors in the same model. The prediction accuracy of the NLR for the early growth of tICH in patients is 82%. Interpretation The NLR is easily calculated and might predict the early growth of tICH for patients suffering from TBI.https://doi.org/10.1002/acn3.51409 |
| spellingShingle | Dongzhou Zhuang Jiangtao Sheng Guoyi Peng Tian Li Shirong Cai Faxiu Din Lianjie Li Mindong Huang Fei Tian Kangsheng Li Shousen Wang Weiqiang Chen Neutrophil to lymphocyte ratio predicts early growth of traumatic intracerebral haemorrhage Annals of Clinical and Translational Neurology |
| title | Neutrophil to lymphocyte ratio predicts early growth of traumatic intracerebral haemorrhage |
| title_full | Neutrophil to lymphocyte ratio predicts early growth of traumatic intracerebral haemorrhage |
| title_fullStr | Neutrophil to lymphocyte ratio predicts early growth of traumatic intracerebral haemorrhage |
| title_full_unstemmed | Neutrophil to lymphocyte ratio predicts early growth of traumatic intracerebral haemorrhage |
| title_short | Neutrophil to lymphocyte ratio predicts early growth of traumatic intracerebral haemorrhage |
| title_sort | neutrophil to lymphocyte ratio predicts early growth of traumatic intracerebral haemorrhage |
| url | https://doi.org/10.1002/acn3.51409 |
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