MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans.
Forming the proper number of synapses is crucial for normal neuronal development. We found that loss of function of the phosphoinositide phosphatase mtm-6 results in a reduction in the number of synaptic puncta. The reduction in synapses is partially the result of MTM-6 regulation of the secretion o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4257696?pdf=render |
| _version_ | 1828384111033581568 |
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| author | Vivian R Ericson Kerri A Spilker Madina S Tugizova Kang Shen |
| author_facet | Vivian R Ericson Kerri A Spilker Madina S Tugizova Kang Shen |
| author_sort | Vivian R Ericson |
| collection | DOAJ |
| description | Forming the proper number of synapses is crucial for normal neuronal development. We found that loss of function of the phosphoinositide phosphatase mtm-6 results in a reduction in the number of synaptic puncta. The reduction in synapses is partially the result of MTM-6 regulation of the secretion of the Wnt ligand EGL-20 from cells in the tail and partially the result of neuronal action. MTM-6 shows relative specificity for EGL-20 over the other Wnt ligands. We suggest that the ability of MTM-6 to regulate EGL-20 secretion is a function of its expression pattern. We conclude that regulation of secretion of different Wnt ligands can use different components. Additionally, we present a novel neuronal function for MTM-6. |
| first_indexed | 2024-12-10T04:58:12Z |
| format | Article |
| id | doaj.art-4f2567c7b7e247e199edc9e9c0a90a50 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T04:58:12Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4f2567c7b7e247e199edc9e9c0a90a502022-12-22T02:01:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11450110.1371/journal.pone.0114501MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans.Vivian R EricsonKerri A SpilkerMadina S TugizovaKang ShenForming the proper number of synapses is crucial for normal neuronal development. We found that loss of function of the phosphoinositide phosphatase mtm-6 results in a reduction in the number of synaptic puncta. The reduction in synapses is partially the result of MTM-6 regulation of the secretion of the Wnt ligand EGL-20 from cells in the tail and partially the result of neuronal action. MTM-6 shows relative specificity for EGL-20 over the other Wnt ligands. We suggest that the ability of MTM-6 to regulate EGL-20 secretion is a function of its expression pattern. We conclude that regulation of secretion of different Wnt ligands can use different components. Additionally, we present a novel neuronal function for MTM-6.http://europepmc.org/articles/PMC4257696?pdf=render |
| spellingShingle | Vivian R Ericson Kerri A Spilker Madina S Tugizova Kang Shen MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans. PLoS ONE |
| title | MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans. |
| title_full | MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans. |
| title_fullStr | MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans. |
| title_full_unstemmed | MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans. |
| title_short | MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans. |
| title_sort | mtm 6 a phosphoinositide phosphatase is required to promote synapse formation in caenorhabditis elegans |
| url | http://europepmc.org/articles/PMC4257696?pdf=render |
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