Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma

Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma

Introduction: The PD-1/PD-L1 axis is hijacked by lung adenocarcinoma (LUAD) cells to escape immune surveillance. PD-L1 expression in LUAD is affected, among others, by the metabolic trafficking between tumor cells and the tumor microenvironment (TME).Methods: Correlation between PD-L1 expression and...

Full description

Bibliographic Details
Main Authors: Anna Martina Battaglia, Alessandro Sacco, Ilenia Aversa, Gianluca Santamaria, Camillo Palmieri, Cirino Botta, Roberto De Stefano, Maurizio Bitetto, Lavinia Petriaggi, Emanuele Giorgio, Concetta Maria Faniello, Francesco Costanzo, Flavia Biamonte
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
iron
PD-L1
TME
lung adenocarcinoma
oxidative stress
c-Myc
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1208485/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1208485/full

Similar Items