Profile of a patient with stable coronary artery disease and impaired muscle status
Aim. To determine the clinical profile of a patient with stable coronary artery disease (CAD) and impaired muscle status.Material and methods. The study included 387 patients with stable CAD who had indications for open myocardial revascularization. Quantification of muscle tissue was carried out us...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2023-01-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/3454 |
| _version_ | 1797882243232825344 |
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| author | A. N. Kokov A. I. Masenko A. I. Kareeva K. E. Krivoshapova O. L. Barbarash |
| author_facet | A. N. Kokov A. I. Masenko A. I. Kareeva K. E. Krivoshapova O. L. Barbarash |
| author_sort | A. N. Kokov |
| collection | DOAJ |
| description | Aim. To determine the clinical profile of a patient with stable coronary artery disease (CAD) and impaired muscle status.Material and methods. The study included 387 patients with stable CAD who had indications for open myocardial revascularization. Quantification of muscle tissue was carried out using computed tomography. Comparative analysis of clinical and anamnestic characteristics of groups of patients with sarcopenia (n=152) and those with normal muscle status (n=235) was performed.Results. Signs of sarcopenia were found in 39,3% of patients with stable CAD. In the group of sarcopenia and the group with normal muscle status, there was a predominance of males — 86,2 and 64,7% (p=0,01), the presence of hypercholesterolemia — 51,3 and 31,1% (p=0,02), type 2 diabetes — 21,1 and 28,1% (p=0,06), multivessel CAD — 25,6 and 17,8% of cases (p=0,018), respectively. In sarcopenia, a 4 times longer history of diabetes was noted (p=0,01) and a 2,3 times longer duration of CAD (p=0,03). The prevalence of obesity in sarcopenia was 3,4 times less (p=0,003). Correlation analysis showed the relationship of muscle status with age (r=-0,674; p=0,002), duration of CAD history (r=-0,582; p=0,001) and diabetes (r=-0,748; p<0,001).Conclusion. The clinical and anamnestic profile of a patient with stable CAD and sarcopenia is characterized by an association of decreased muscle mass with male sex, hypercholesterolemia, multivessel coronary CAD, a long-term history of type 2 diabetes and angina. |
| first_indexed | 2024-04-10T03:32:55Z |
| format | Article |
| id | doaj.art-4f28105dacaf4532aeee2aa369476456 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:32:55Z |
| publishDate | 2023-01-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-4f28105dacaf4532aeee2aa3694764562023-03-13T07:23:34Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252023-01-01211210.15829/1728-8800-2022-34542597Profile of a patient with stable coronary artery disease and impaired muscle statusA. N. Kokov0A. I. Masenko1A. I. Kareeva2K. E. Krivoshapova3O. L. Barbarash4ФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийAim. To determine the clinical profile of a patient with stable coronary artery disease (CAD) and impaired muscle status.Material and methods. The study included 387 patients with stable CAD who had indications for open myocardial revascularization. Quantification of muscle tissue was carried out using computed tomography. Comparative analysis of clinical and anamnestic characteristics of groups of patients with sarcopenia (n=152) and those with normal muscle status (n=235) was performed.Results. Signs of sarcopenia were found in 39,3% of patients with stable CAD. In the group of sarcopenia and the group with normal muscle status, there was a predominance of males — 86,2 and 64,7% (p=0,01), the presence of hypercholesterolemia — 51,3 and 31,1% (p=0,02), type 2 diabetes — 21,1 and 28,1% (p=0,06), multivessel CAD — 25,6 and 17,8% of cases (p=0,018), respectively. In sarcopenia, a 4 times longer history of diabetes was noted (p=0,01) and a 2,3 times longer duration of CAD (p=0,03). The prevalence of obesity in sarcopenia was 3,4 times less (p=0,003). Correlation analysis showed the relationship of muscle status with age (r=-0,674; p=0,002), duration of CAD history (r=-0,582; p=0,001) and diabetes (r=-0,748; p<0,001).Conclusion. The clinical and anamnestic profile of a patient with stable CAD and sarcopenia is characterized by an association of decreased muscle mass with male sex, hypercholesterolemia, multivessel coronary CAD, a long-term history of type 2 diabetes and angina.https://cardiovascular.elpub.ru/jour/article/view/3454саркопениякомпьютерная томографияишемическая болезнь сердцаклинический портрет |
| spellingShingle | A. N. Kokov A. I. Masenko A. I. Kareeva K. E. Krivoshapova O. L. Barbarash Profile of a patient with stable coronary artery disease and impaired muscle status Кардиоваскулярная терапия и профилактика саркопения компьютерная томография ишемическая болезнь сердца клинический портрет |
| title | Profile of a patient with stable coronary artery disease and impaired muscle status |
| title_full | Profile of a patient with stable coronary artery disease and impaired muscle status |
| title_fullStr | Profile of a patient with stable coronary artery disease and impaired muscle status |
| title_full_unstemmed | Profile of a patient with stable coronary artery disease and impaired muscle status |
| title_short | Profile of a patient with stable coronary artery disease and impaired muscle status |
| title_sort | profile of a patient with stable coronary artery disease and impaired muscle status |
| topic | саркопения компьютерная томография ишемическая болезнь сердца клинический портрет |
| url | https://cardiovascular.elpub.ru/jour/article/view/3454 |
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