FLOT1 promotes tumor development, induces epithelial–mesenchymal transition, and modulates the cell cycle by regulating the Erk/Akt signaling pathway in lung adenocarcinoma

FLOT1 promotes tumor development, induces epithelial–mesenchymal transition, and modulates the cell cycle by regulating the Erk/Akt signaling pathway in lung adenocarcinoma

Background FLOT1 is a scaffolding protein of lipid rafts that is believed to be involved in numerous cellular processes. However, few studies have explored the function of FLOT1 in the development of lung adenocarcinoma (LUAD) and the underlying mechanisms of FLOT1 activity. Methods FLOT1 knockdown...

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Bibliographic Details
Main Authors: Louqian Zhang, Yuan Mao, Qixing Mao, Weifei Fan, Li Xu, Yan Chen, Lin Xu, Jun Wang
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Thoracic Cancer
Subjects:
FLOT1
lung adenocarcinoma
malignant behavior
signaling pathway
Online Access:https://doi.org/10.1111/1759-7714.13027

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