Oral Adelmidrol Administration Up-Regulates Palmitoylethanolamide Production in Mice Colon and Duodenum through a PPAR-γ Independent Action

Oral Adelmidrol Administration Up-Regulates Palmitoylethanolamide Production in Mice Colon and Duodenum through a PPAR-γ Independent Action

Adelmidrol is a promising palmitoylethanolamide (PEA) analog which displayed up-and-coming anti-inflammatory properties in several inflammatory conditions. Recent studies demonstrated that Adelmidrol is an in vitro enhancer of PEA endogenous production, through the so called “entourage” effect. The...

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Bibliographic Details
Main Authors: Alessandro Del Re, Irene Palenca, Luisa Seguella, Marcella Pesce, Chiara Corpetti, Luca Steardo, Sara Rurgo, Giovanni Sarnelli, Giuseppe Esposito
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Metabolites
Subjects:
adelmidrol
ALIAmides
palmitoylethanolamide
entourage effect
PPAR-γ
Online Access:https://www.mdpi.com/2218-1989/12/5/457

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