Vaccination with a BCG strain overexpressing Ag85B protects cattle against Mycobacterium bovis challenge.

Vaccination with a BCG strain overexpressing Ag85B protects cattle against Mycobacterium bovis challenge.

Mycobacterium bovis is the causative agent of tuberculosis in cattle but also infects other animals, including humans. Previous studies in cattle have demonstrated that the protection induced by BCG is not complete. In order to improve the protection efficacy of BCG, in this study we overexpressed A...

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Bibliographic Details
Main Authors: Caroline Rizzi, María Verónica Bianco, Federico Carlos Blanco, Marcelo Soria, María José Gravisaco, Valeria Montenegro, Lucas Vagnoni, Bryce Buddle, Sergio Garbaccio, Fernando Delgado, Karen Silva Leal, Angel Adrián Cataldi, Odir Antônio Dellagostin, Fabiana Bigi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3519572?pdf=render

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