Salivary Eosinophil Cationic Protein in Allergic Rhinitis
Objective: Eosinophil cationic protein (ECP) plays a significant role in the pathogenesis of atopic diseases such as allergic rhinitis (AR) and asthma. Using saliva as a diagnostic material is a non-invasive, simple method. Analysis of ECP in saliva was shown as an alternative diagnostic contributio...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2019-06-01
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| Series: | Turkish Archives of Otorhinolaryngology |
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http://turkarchotolaryngol.net/archives/archive-detail/article-preview/salivary-eosinophil-cationic-protein-in-allergic-r/43100
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| author | Tolga Kırgezen Ela Araz Server Fulya Savran Turanoğlu Özgür Yiğit Hafize Uzun Sinem Durmuş |
| author_facet | Tolga Kırgezen Ela Araz Server Fulya Savran Turanoğlu Özgür Yiğit Hafize Uzun Sinem Durmuş |
| author_sort | Tolga Kırgezen |
| collection | DOAJ |
| description | Objective: Eosinophil cationic protein (ECP) plays a significant role in the pathogenesis of atopic diseases such as allergic rhinitis (AR) and asthma. Using saliva as a diagnostic material is a non-invasive, simple method. Analysis of ECP in saliva was shown as an alternative diagnostic contribution in patients with asthma. In this study we aimed to assess a possible association between the levels of salivary ECP and the diagnosis of AR by comparing serum ECP and salivary ECP levels.Methods: Thirty-five allergic rhinitis patients (study group) sensitive to Dermatophagoides farinae (D2) in skin prick test (SPT) and 35 nonallergic, SPT negative, healthy volunteers (control group) were included in the study. Salivary ECP, serum ECP and specific IgE D2 levels were measured.Results: Distribution of age and gender were similar in the study and the control groups (p>0.05). Serum specific IgE D2 levels were significantly higher in the study group compared to the control group (p<0.001). ECP levels in saliva and serum did not show any significant difference in between study and control groups (p=0.738; p=0.796, respectively). No significant difference was found between the levels of ECP in between the serum and the saliva of study and control groups. (p=0.504; p=0.589, respectively). There was no significant correlation between saliva and serum ECP levels of both groups.(r=-0.191/ p=0.114).Conclusion: Serum and saliva ECP levels seem close to each other and were comparable in both groups, but we did not find any correlation between them Although we hypothesized that saliva ECP may be used as a non-invasive method for the diagnosis of AR, it seems that this parameter is not helpful in diagnosis of AR. |
| first_indexed | 2024-04-10T13:37:48Z |
| format | Article |
| id | doaj.art-4f2b7becf19a4cfb82b91bb9cf931804 |
| institution | Directory Open Access Journal |
| issn | 2667-7474 |
| language | English |
| last_indexed | 2024-04-10T13:37:48Z |
| publishDate | 2019-06-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Turkish Archives of Otorhinolaryngology |
| spelling | doaj.art-4f2b7becf19a4cfb82b91bb9cf9318042023-02-15T16:11:19ZengGalenos YayincilikTurkish Archives of Otorhinolaryngology2667-74742019-06-01572919410.5152/tao.2019.412713049054Salivary Eosinophil Cationic Protein in Allergic RhinitisTolga Kırgezen0Ela Araz Server1Fulya Savran Turanoğlu2Özgür Yiğit3Hafize Uzun4Sinem Durmuş5 Department of Otorhinolaryngology, İstanbul Training and Research Hospital, İstanbul, Turkey Department of Otorhinolaryngology, İstanbul Training and Research Hospital, İstanbul, Turkey Department of Otorhinolaryngology, İstanbul Training and Research Hospital, İstanbul, Turkey Department of Otorhinolaryngology, İstanbul Training and Research Hospital, İstanbul, Turkey Department of Biochemistry, İstanbul University, Cerrahpaşa School of Medicine, İstanbul, Turkey Department of Biochemistry, İstanbul University, Cerrahpaşa School of Medicine, İstanbul, Turkey Objective: Eosinophil cationic protein (ECP) plays a significant role in the pathogenesis of atopic diseases such as allergic rhinitis (AR) and asthma. Using saliva as a diagnostic material is a non-invasive, simple method. Analysis of ECP in saliva was shown as an alternative diagnostic contribution in patients with asthma. In this study we aimed to assess a possible association between the levels of salivary ECP and the diagnosis of AR by comparing serum ECP and salivary ECP levels.Methods: Thirty-five allergic rhinitis patients (study group) sensitive to Dermatophagoides farinae (D2) in skin prick test (SPT) and 35 nonallergic, SPT negative, healthy volunteers (control group) were included in the study. Salivary ECP, serum ECP and specific IgE D2 levels were measured.Results: Distribution of age and gender were similar in the study and the control groups (p>0.05). Serum specific IgE D2 levels were significantly higher in the study group compared to the control group (p<0.001). ECP levels in saliva and serum did not show any significant difference in between study and control groups (p=0.738; p=0.796, respectively). No significant difference was found between the levels of ECP in between the serum and the saliva of study and control groups. (p=0.504; p=0.589, respectively). There was no significant correlation between saliva and serum ECP levels of both groups.(r=-0.191/ p=0.114).Conclusion: Serum and saliva ECP levels seem close to each other and were comparable in both groups, but we did not find any correlation between them Although we hypothesized that saliva ECP may be used as a non-invasive method for the diagnosis of AR, it seems that this parameter is not helpful in diagnosis of AR. http://turkarchotolaryngol.net/archives/archive-detail/article-preview/salivary-eosinophil-cationic-protein-in-allergic-r/43100 allergic rhinitiseosinophil cationic proteinsalivaskin prick testallergy |
| spellingShingle | Tolga Kırgezen Ela Araz Server Fulya Savran Turanoğlu Özgür Yiğit Hafize Uzun Sinem Durmuş Salivary Eosinophil Cationic Protein in Allergic Rhinitis Turkish Archives of Otorhinolaryngology allergic rhinitis eosinophil cationic protein saliva skin prick test allergy |
| title | Salivary Eosinophil Cationic Protein in Allergic Rhinitis |
| title_full | Salivary Eosinophil Cationic Protein in Allergic Rhinitis |
| title_fullStr | Salivary Eosinophil Cationic Protein in Allergic Rhinitis |
| title_full_unstemmed | Salivary Eosinophil Cationic Protein in Allergic Rhinitis |
| title_short | Salivary Eosinophil Cationic Protein in Allergic Rhinitis |
| title_sort | salivary eosinophil cationic protein in allergic rhinitis |
| topic | allergic rhinitis eosinophil cationic protein saliva skin prick test allergy |
| url |
http://turkarchotolaryngol.net/archives/archive-detail/article-preview/salivary-eosinophil-cationic-protein-in-allergic-r/43100
|
| work_keys_str_mv | AT tolgakırgezen salivaryeosinophilcationicproteininallergicrhinitis AT elaarazserver salivaryeosinophilcationicproteininallergicrhinitis AT fulyasavranturanoglu salivaryeosinophilcationicproteininallergicrhinitis AT ozguryigit salivaryeosinophilcationicproteininallergicrhinitis AT hafizeuzun salivaryeosinophilcationicproteininallergicrhinitis AT sinemdurmus salivaryeosinophilcationicproteininallergicrhinitis |