A Hydrophilic Interaction Liquid Chromatography–Tandem Mass Spectrometry Quantitative Method for Determination of Baricitinib in Plasma, and Its Application in a Pharmacokinetic Study in Rats

A Hydrophilic Interaction Liquid Chromatography–Tandem Mass Spectrometry Quantitative Method for Determination of Baricitinib in Plasma, and Its Application in a Pharmacokinetic Study in Rats

Baricitinib, is a selective and reversible Janus kinase inhibitor, is commonly used to treat adult patients with moderately to severely active rheumatoid arthritis (RA). A fast, reproducible and sensitive method of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the quantification of b...

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Bibliographic Details
Main Authors: Essam Ezzeldin, Muzaffar Iqbal, Yousif A. Asiri, Azza A Ali, Prawez Alam, Toqa El-Nahhas
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
baricitinib
UPLC-MS/MS
pharmacokinetic study
irbersartan
Online Access:https://www.mdpi.com/1420-3049/25/7/1600

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