Rodents as Hosts of Pathogens and Related Zoonotic Disease Risk
Rodents are known to be reservoir hosts for at least 60 zoonotic diseases and are known to play an important role in their transmission and spread in different ways. We sampled different rodent communities within and around human settlements in Northern Senegal, an area subjected to major environmen...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/3/202 |
| _version_ | 1811187257675087872 |
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| author | Handi Dahmana Laurent Granjon Christophe Diagne Bernard Davoust Florence Fenollar Oleg Mediannikov |
| author_facet | Handi Dahmana Laurent Granjon Christophe Diagne Bernard Davoust Florence Fenollar Oleg Mediannikov |
| author_sort | Handi Dahmana |
| collection | DOAJ |
| description | Rodents are known to be reservoir hosts for at least 60 zoonotic diseases and are known to play an important role in their transmission and spread in different ways. We sampled different rodent communities within and around human settlements in Northern Senegal, an area subjected to major environmental transformations associated with global changes. Herein, we conducted an epidemiological study on their bacterial communities. One hundred and seventy-one (171) invasive and native rodents were captured, 50 from outdoor trapping sites and 121 rodents from indoor habitats, consisting of five species. The DNA of thirteen pathogens was successfully screened on the rodents’ spleens. We found: 2.3% of spleens positive to <i>Piroplasmida</i> and amplified one which gave a potentially new species <i>Candidatus</i> “<i>Theileria senegalensis</i>”; 9.35% of <i>Bartonella</i> spp. and amplified 10, giving three genotypes; 3.5% of filariasis species; 18.12% of <i>Anaplasmataceae</i> species and amplified only 5, giving a new potential species <i>Candidatus</i> “<i>Ehrlichia senegalensis</i>”; 2.33% of <i>Hepatozoon</i> spp.; 3.5% of <i>Kinetoplastidae</i> spp.; and 15.2% of <i>Borrelia</i> spp. and amplified 8 belonging all to <i>Borrelia crocidurae.</i> Some of the species of pathogens carried by the rodents of our studied area may be unknown because most of those we have identified are new species. In one bacterial taxon, <i>Anaplasma</i>, a positive correlation between host body mass and infection was found. Overall, male and invasive rodents appeared less infected than female and native ones, respectively. |
| first_indexed | 2024-04-11T13:59:14Z |
| format | Article |
| id | doaj.art-4f3309cbe89d4708a20160bcf6cba6c0 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-11T13:59:14Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-4f3309cbe89d4708a20160bcf6cba6c02022-12-22T04:20:10ZengMDPI AGPathogens2076-08172020-03-019320210.3390/pathogens9030202pathogens9030202Rodents as Hosts of Pathogens and Related Zoonotic Disease RiskHandi Dahmana0Laurent Granjon1Christophe Diagne2Bernard Davoust3Florence Fenollar4Oleg Mediannikov5Aix-Marseille University, IRD, AP-HM, MEPHI, 13005 Marseille, FranceCBGP, IRD, CIRAD, INRA, Montpellier SupAgro, University Montpellier, 34980 Montpellier, FranceCBGP, IRD, CIRAD, INRA, Montpellier SupAgro, University Montpellier, 34980 Montpellier, FranceAix-Marseille University, IRD, AP-HM, MEPHI, 13005 Marseille, FranceIHU-Méditerranée Infection, 13005 Marseille, FranceAix-Marseille University, IRD, AP-HM, MEPHI, 13005 Marseille, FranceRodents are known to be reservoir hosts for at least 60 zoonotic diseases and are known to play an important role in their transmission and spread in different ways. We sampled different rodent communities within and around human settlements in Northern Senegal, an area subjected to major environmental transformations associated with global changes. Herein, we conducted an epidemiological study on their bacterial communities. One hundred and seventy-one (171) invasive and native rodents were captured, 50 from outdoor trapping sites and 121 rodents from indoor habitats, consisting of five species. The DNA of thirteen pathogens was successfully screened on the rodents’ spleens. We found: 2.3% of spleens positive to <i>Piroplasmida</i> and amplified one which gave a potentially new species <i>Candidatus</i> “<i>Theileria senegalensis</i>”; 9.35% of <i>Bartonella</i> spp. and amplified 10, giving three genotypes; 3.5% of filariasis species; 18.12% of <i>Anaplasmataceae</i> species and amplified only 5, giving a new potential species <i>Candidatus</i> “<i>Ehrlichia senegalensis</i>”; 2.33% of <i>Hepatozoon</i> spp.; 3.5% of <i>Kinetoplastidae</i> spp.; and 15.2% of <i>Borrelia</i> spp. and amplified 8 belonging all to <i>Borrelia crocidurae.</i> Some of the species of pathogens carried by the rodents of our studied area may be unknown because most of those we have identified are new species. In one bacterial taxon, <i>Anaplasma</i>, a positive correlation between host body mass and infection was found. Overall, male and invasive rodents appeared less infected than female and native ones, respectively.https://www.mdpi.com/2076-0817/9/3/202pathogens hostzoonotic diseaserodents<i>bartonella</i><i>borrelia crocidurae</i>anaplasmataceaepiroplasmida<i>hepatozoon</i> |
| spellingShingle | Handi Dahmana Laurent Granjon Christophe Diagne Bernard Davoust Florence Fenollar Oleg Mediannikov Rodents as Hosts of Pathogens and Related Zoonotic Disease Risk Pathogens pathogens host zoonotic disease rodents <i>bartonella</i> <i>borrelia crocidurae</i> anaplasmataceae piroplasmida <i>hepatozoon</i> |
| title | Rodents as Hosts of Pathogens and Related Zoonotic Disease Risk |
| title_full | Rodents as Hosts of Pathogens and Related Zoonotic Disease Risk |
| title_fullStr | Rodents as Hosts of Pathogens and Related Zoonotic Disease Risk |
| title_full_unstemmed | Rodents as Hosts of Pathogens and Related Zoonotic Disease Risk |
| title_short | Rodents as Hosts of Pathogens and Related Zoonotic Disease Risk |
| title_sort | rodents as hosts of pathogens and related zoonotic disease risk |
| topic | pathogens host zoonotic disease rodents <i>bartonella</i> <i>borrelia crocidurae</i> anaplasmataceae piroplasmida <i>hepatozoon</i> |
| url | https://www.mdpi.com/2076-0817/9/3/202 |
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