Factors Associated with Cancer-Related Pain Requiring High-Dose Opioid Use in Palliative Cancer Patients
Background: There are no universal tools to predict the necessity of high-dose opioid use for cancer-related pain. Early recognition and interventions for intractable cancer pain could minimize the distress of palliative patients. Objective: We sought to identify the clinical factors associated with...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Mary Ann Liebert
2021-09-01
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| Series: | Palliative Medicine Reports |
| Subjects: | |
| Online Access: | https://www.liebertpub.com/doi/full/10.1089/PMR.2021.0037 |
| _version_ | 1827374102740992000 |
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| author | Hidetoshi Sumimoto Komaki Hayashi Yuri Kimura Akihito Nishikawa Seiko Hattori Chiaki Hasegawa Hiroaki Morii Koji Teramoto Sachiyo Morita Yataro Daigo |
| author_facet | Hidetoshi Sumimoto Komaki Hayashi Yuri Kimura Akihito Nishikawa Seiko Hattori Chiaki Hasegawa Hiroaki Morii Koji Teramoto Sachiyo Morita Yataro Daigo |
| author_sort | Hidetoshi Sumimoto |
| collection | DOAJ |
| description | Background: There are no universal tools to predict the necessity of high-dose opioid use for cancer-related pain. Early recognition and interventions for intractable cancer pain could minimize the distress of palliative patients.
Objective: We sought to identify the clinical factors associated with high-dose opioid use in advanced cancer patients to recognize palliative patients who would develop intractable cancer pain, as early as possible.
Setting/Subjects: Among 385 in-hospital cancer patients from April 1, 2014 to July 31, 2019, who were referred to the palliative care team for cancer-related pain, clinical factors significantly correlated to high-dose opioid use were retrospectively analyzed.
Measurements: We conducted a multiple logistic regression analysis to identify variables significantly related to high-dose opioid use (>120?mg/day oral morphine equivalent dose).
Results: Independent factors of high-dose opioid use included younger age (odds ratio [OR] 0.965, 95% confidence interval [CI] 0.944?0.986, p?=?0.001), respiratory cancers (OR 1.882, 95% CI 1.069?3.312, p?<?0.001), and opioid switch (OR 2.869, 95% CI 1.497?5.497, p?=?0.001). The percentage of correct classifications of the regression equation was 86.9%.
Conclusions: Younger age, respiratory cancers, and opioid switch were related to high-dose opioid use. Our findings may help palliative caregivers to deal with intractable cancer pain in palliative patients, and thus relieve their distress. |
| first_indexed | 2024-03-08T11:27:44Z |
| format | Article |
| id | doaj.art-4f36d8ea98cc44368c5397637a853499 |
| institution | Directory Open Access Journal |
| issn | 2689-2820 |
| language | English |
| last_indexed | 2024-03-08T11:27:44Z |
| publishDate | 2021-09-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Palliative Medicine Reports |
| spelling | doaj.art-4f36d8ea98cc44368c5397637a8534992024-01-26T04:53:06ZengMary Ann LiebertPalliative Medicine Reports2689-28202021-09-012123724110.1089/PMR.2021.0037Factors Associated with Cancer-Related Pain Requiring High-Dose Opioid Use in Palliative Cancer PatientsHidetoshi SumimotoKomaki HayashiYuri KimuraAkihito NishikawaSeiko HattoriChiaki HasegawaHiroaki MoriiKoji TeramotoSachiyo MoritaYataro DaigoBackground: There are no universal tools to predict the necessity of high-dose opioid use for cancer-related pain. Early recognition and interventions for intractable cancer pain could minimize the distress of palliative patients. Objective: We sought to identify the clinical factors associated with high-dose opioid use in advanced cancer patients to recognize palliative patients who would develop intractable cancer pain, as early as possible. Setting/Subjects: Among 385 in-hospital cancer patients from April 1, 2014 to July 31, 2019, who were referred to the palliative care team for cancer-related pain, clinical factors significantly correlated to high-dose opioid use were retrospectively analyzed. Measurements: We conducted a multiple logistic regression analysis to identify variables significantly related to high-dose opioid use (>120?mg/day oral morphine equivalent dose). Results: Independent factors of high-dose opioid use included younger age (odds ratio [OR] 0.965, 95% confidence interval [CI] 0.944?0.986, p?=?0.001), respiratory cancers (OR 1.882, 95% CI 1.069?3.312, p?<?0.001), and opioid switch (OR 2.869, 95% CI 1.497?5.497, p?=?0.001). The percentage of correct classifications of the regression equation was 86.9%. Conclusions: Younger age, respiratory cancers, and opioid switch were related to high-dose opioid use. Our findings may help palliative caregivers to deal with intractable cancer pain in palliative patients, and thus relieve their distress.https://www.liebertpub.com/doi/full/10.1089/PMR.2021.0037cancer-related painintractable cancer painhigh-dose opioid |
| spellingShingle | Hidetoshi Sumimoto Komaki Hayashi Yuri Kimura Akihito Nishikawa Seiko Hattori Chiaki Hasegawa Hiroaki Morii Koji Teramoto Sachiyo Morita Yataro Daigo Factors Associated with Cancer-Related Pain Requiring High-Dose Opioid Use in Palliative Cancer Patients Palliative Medicine Reports cancer-related pain intractable cancer pain high-dose opioid |
| title | Factors Associated with Cancer-Related Pain Requiring High-Dose Opioid Use in Palliative Cancer Patients |
| title_full | Factors Associated with Cancer-Related Pain Requiring High-Dose Opioid Use in Palliative Cancer Patients |
| title_fullStr | Factors Associated with Cancer-Related Pain Requiring High-Dose Opioid Use in Palliative Cancer Patients |
| title_full_unstemmed | Factors Associated with Cancer-Related Pain Requiring High-Dose Opioid Use in Palliative Cancer Patients |
| title_short | Factors Associated with Cancer-Related Pain Requiring High-Dose Opioid Use in Palliative Cancer Patients |
| title_sort | factors associated with cancer related pain requiring high dose opioid use in palliative cancer patients |
| topic | cancer-related pain intractable cancer pain high-dose opioid |
| url | https://www.liebertpub.com/doi/full/10.1089/PMR.2021.0037 |
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