High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila
The function of the central nervous system to regulate food intake can be disrupted by sustained metabolic challenges such as high-fat diet (HFD), which may contribute to various metabolic disorders. Previously, we showed that a group of octopaminergic (OA) neurons mediated starvation-induced hypera...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-04-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/53103 |
| _version_ | 1811200424431058944 |
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| author | Rui Huang Tingting Song Haifeng Su Zeliang Lai Wusa Qin Yinjun Tian Xuan Dong Liming Wang |
| author_facet | Rui Huang Tingting Song Haifeng Su Zeliang Lai Wusa Qin Yinjun Tian Xuan Dong Liming Wang |
| author_sort | Rui Huang |
| collection | DOAJ |
| description | The function of the central nervous system to regulate food intake can be disrupted by sustained metabolic challenges such as high-fat diet (HFD), which may contribute to various metabolic disorders. Previously, we showed that a group of octopaminergic (OA) neurons mediated starvation-induced hyperactivity, an important aspect of food-seeking behavior (Yu et al., 2016). Here we find that HFD specifically enhances this behavior. Mechanistically, HFD increases the excitability of these OA neurons to a hunger hormone named adipokinetic hormone (AKH), via increasing the accumulation of AKH receptor (AKHR) in these neurons. Upon HFD, excess dietary lipids are transported by a lipoprotein LTP to enter these OA+AKHR+ neurons via the cognate receptor LpR1, which in turn suppresses autophagy-dependent degradation of AKHR. Taken together, we uncover a mechanism that links HFD, neuronal autophagy, and starvation-induced hyperactivity, providing insight in the reshaping of neural circuitry under metabolic challenges and the progression of metabolic diseases. |
| first_indexed | 2024-04-12T02:04:23Z |
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| id | doaj.art-4f3796f89e804840a3d7dc8b869cc0c7 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:04:23Z |
| publishDate | 2020-04-01 |
| publisher | eLife Sciences Publications Ltd |
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| spelling | doaj.art-4f3796f89e804840a3d7dc8b869cc0c72022-12-22T03:52:35ZengeLife Sciences Publications LtdeLife2050-084X2020-04-01910.7554/eLife.53103High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in DrosophilaRui Huang0https://orcid.org/0000-0003-4656-1682Tingting Song1Haifeng Su2Zeliang Lai3Wusa Qin4Yinjun Tian5Xuan Dong6Liming Wang7https://orcid.org/0000-0002-7256-8776Center for Neurointelligence, School of Medicine, Chongqing University & Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College, Chongqing University, Chongqing, China; Shenzhen Bay Laboratory, Shenzhen, ChinaShenzhen Bay Laboratory, Shenzhen, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, ChinaCenter for Neurointelligence, School of Medicine, Chongqing University & Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College, Chongqing University, Chongqing, China; Shenzhen Bay Laboratory, Shenzhen, ChinaShenzhen Bay Laboratory, Shenzhen, ChinaMOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, ChinaMOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, ChinaMOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, ChinaThe function of the central nervous system to regulate food intake can be disrupted by sustained metabolic challenges such as high-fat diet (HFD), which may contribute to various metabolic disorders. Previously, we showed that a group of octopaminergic (OA) neurons mediated starvation-induced hyperactivity, an important aspect of food-seeking behavior (Yu et al., 2016). Here we find that HFD specifically enhances this behavior. Mechanistically, HFD increases the excitability of these OA neurons to a hunger hormone named adipokinetic hormone (AKH), via increasing the accumulation of AKH receptor (AKHR) in these neurons. Upon HFD, excess dietary lipids are transported by a lipoprotein LTP to enter these OA+AKHR+ neurons via the cognate receptor LpR1, which in turn suppresses autophagy-dependent degradation of AKHR. Taken together, we uncover a mechanism that links HFD, neuronal autophagy, and starvation-induced hyperactivity, providing insight in the reshaping of neural circuitry under metabolic challenges and the progression of metabolic diseases.https://elifesciences.org/articles/53103autophagyforagingoctopaminefeedingAKHR |
| spellingShingle | Rui Huang Tingting Song Haifeng Su Zeliang Lai Wusa Qin Yinjun Tian Xuan Dong Liming Wang High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila eLife autophagy foraging octopamine feeding AKHR |
| title | High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila |
| title_full | High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila |
| title_fullStr | High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila |
| title_full_unstemmed | High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila |
| title_short | High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila |
| title_sort | high fat diet enhances starvation induced hyperactivity via sensitizing hunger sensing neurons in drosophila |
| topic | autophagy foraging octopamine feeding AKHR |
| url | https://elifesciences.org/articles/53103 |
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