Postmortem Analysis of Vitreous Urea Nitrogen, Creatinine, and Magnesium of Renal and Post-Renal Disease in Cats
Analysis of vitreous urea nitrogen (VUN) and creatinine (CREA) has been shown to be a useful indicator of azotemia in human postmortem examinations. Previous studies in cats, dogs, horses, and cattle have shown a good correlation between serum and postmortem ocular fluid for urea and creatinine. The...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/8/685 |
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| author | Adam W. Stern Daliana Roig Courtney Valerio Thomas Denagamage |
| author_facet | Adam W. Stern Daliana Roig Courtney Valerio Thomas Denagamage |
| author_sort | Adam W. Stern |
| collection | DOAJ |
| description | Analysis of vitreous urea nitrogen (VUN) and creatinine (CREA) has been shown to be a useful indicator of azotemia in human postmortem examinations. Previous studies in cats, dogs, horses, and cattle have shown a good correlation between serum and postmortem ocular fluid for urea and creatinine. The aim of this study was to evaluate differences in VUN, CREA, and magnesium (MG) concentrations in vitreous humor collected postmortem from cats that presented with renal or post-renal disease and cats without renal or post-renal disease. Nine cats with renal or post-renal disease and twenty cats without renal or post-renal disease that underwent autopsy were used in this study. Collection of postmortem vitreous humor was performed, and vitreous samples were frozen at −80 °C for a minimum of 24 h prior to analysis using an in-clinic dry chemistry analyzer. Overall, there were statistically significant differences for VUN, CREA, and MG between cats with renal or post-renal disease and cats without renal or post-renal disease. Analysis of vitreous humor from cats suspected to have renal or post-renal disease can provide useful diagnostic information pertaining to renal function and issues in the urethra and urinary bladder. Future studies exploring postmortem vitreous chemistry in cats are warranted. |
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| format | Article |
| id | doaj.art-4f387bd3403242f3af06349e8e231daf |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T23:31:32Z |
| publishDate | 2023-08-01 |
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| series | Toxics |
| spelling | doaj.art-4f387bd3403242f3af06349e8e231daf2023-11-19T03:14:36ZengMDPI AGToxics2305-63042023-08-0111868510.3390/toxics11080685Postmortem Analysis of Vitreous Urea Nitrogen, Creatinine, and Magnesium of Renal and Post-Renal Disease in CatsAdam W. Stern0Daliana Roig1Courtney Valerio2Thomas Denagamage3College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USACollege of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USACollege of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USACollege of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USAAnalysis of vitreous urea nitrogen (VUN) and creatinine (CREA) has been shown to be a useful indicator of azotemia in human postmortem examinations. Previous studies in cats, dogs, horses, and cattle have shown a good correlation between serum and postmortem ocular fluid for urea and creatinine. The aim of this study was to evaluate differences in VUN, CREA, and magnesium (MG) concentrations in vitreous humor collected postmortem from cats that presented with renal or post-renal disease and cats without renal or post-renal disease. Nine cats with renal or post-renal disease and twenty cats without renal or post-renal disease that underwent autopsy were used in this study. Collection of postmortem vitreous humor was performed, and vitreous samples were frozen at −80 °C for a minimum of 24 h prior to analysis using an in-clinic dry chemistry analyzer. Overall, there were statistically significant differences for VUN, CREA, and MG between cats with renal or post-renal disease and cats without renal or post-renal disease. Analysis of vitreous humor from cats suspected to have renal or post-renal disease can provide useful diagnostic information pertaining to renal function and issues in the urethra and urinary bladder. Future studies exploring postmortem vitreous chemistry in cats are warranted.https://www.mdpi.com/2305-6304/11/8/685vitreouspostmortemcatcreatinineurea nitrogenmagnesium |
| spellingShingle | Adam W. Stern Daliana Roig Courtney Valerio Thomas Denagamage Postmortem Analysis of Vitreous Urea Nitrogen, Creatinine, and Magnesium of Renal and Post-Renal Disease in Cats Toxics vitreous postmortem cat creatinine urea nitrogen magnesium |
| title | Postmortem Analysis of Vitreous Urea Nitrogen, Creatinine, and Magnesium of Renal and Post-Renal Disease in Cats |
| title_full | Postmortem Analysis of Vitreous Urea Nitrogen, Creatinine, and Magnesium of Renal and Post-Renal Disease in Cats |
| title_fullStr | Postmortem Analysis of Vitreous Urea Nitrogen, Creatinine, and Magnesium of Renal and Post-Renal Disease in Cats |
| title_full_unstemmed | Postmortem Analysis of Vitreous Urea Nitrogen, Creatinine, and Magnesium of Renal and Post-Renal Disease in Cats |
| title_short | Postmortem Analysis of Vitreous Urea Nitrogen, Creatinine, and Magnesium of Renal and Post-Renal Disease in Cats |
| title_sort | postmortem analysis of vitreous urea nitrogen creatinine and magnesium of renal and post renal disease in cats |
| topic | vitreous postmortem cat creatinine urea nitrogen magnesium |
| url | https://www.mdpi.com/2305-6304/11/8/685 |
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