Oncolytic Adenovirus Armed with a Novel Agonist of the CD137 Immune Checkpoint Stimulator Suppresses Tumor Growth

Oncolytic Adenovirus Armed with a Novel Agonist of the CD137 Immune Checkpoint Stimulator Suppresses Tumor Growth

Natural 4-1BBL (CD137L) is a cell membrane-bound protein critical to the expansion, effector function, and survival of CD8<sup>+</sup> T cells. We reported the generation of an active soluble oligomeric construct, SA-4-1BBL, with demonstrated immunoprevention and immunotherapeutic effica...

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Bibliographic Details
Main Authors: Martin R. Ramos-Gonzalez, Mohammad Tarique, Lalit Batra, Feyza Arguc, Rodolfo Garza-Morales, Haval Shirwan, Esma S. Yolcu, Jorge G. Gomez-Gutierrez
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Vaccines
Subjects:
oncolytic
adenovirus
SA-4-1BBL
lung
cancer
immunotherapy
Online Access:https://www.mdpi.com/2076-393X/12/3/340

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