Developing an algorithm for the management of Renal Cell Carcinoma: focus on metastatic disease
The treatment paradigm in renal cell carcinoma (RCC) is rapidly changing. The incidental finding of small renal tumours combined with the development of novel therapeutic agents targeting the vascular endothelial growth factor (VEGF) or the mammalian target of rapamycin (mTOR) pathways or inhibiting...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2017-06-01
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| Series: | Forum of Clinical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/fco-2015-0025 |
| _version_ | 1818191878402605056 |
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| author | Kyriazoglou Anastasios Dimitriadis Ioannis Bamias Aristotelis |
| author_facet | Kyriazoglou Anastasios Dimitriadis Ioannis Bamias Aristotelis |
| author_sort | Kyriazoglou Anastasios |
| collection | DOAJ |
| description | The treatment paradigm in renal cell carcinoma (RCC) is rapidly changing. The incidental finding of small renal tumours combined with the development of novel therapeutic agents targeting the vascular endothelial growth factor (VEGF) or the mammalian target of rapamycin (mTOR) pathways or inhibiting the interaction of the programmed death 1 (PD 1) receptor with its ligand have dramatically improved the prognosis of patients suffering from this malignancy. At the same time, the availability of multiple effective options with similar indications complicates the development and applicability of guidelines in this disease. We conducted a systematic review of the existing guidelines. Our study revealed areas of agreement as well as of discrepancies amongst the published scientific papers included. By critically evaluating these areas, we developed a therapeutic algorithm for RCC. We suggest that this methodology can define the practices of wide applicability and areas of future research. |
| first_indexed | 2024-12-12T00:21:36Z |
| format | Article |
| id | doaj.art-4f3bc5cc852a4b62ae652c42167541a5 |
| institution | Directory Open Access Journal |
| issn | 1792-362X |
| language | English |
| last_indexed | 2024-12-12T00:21:36Z |
| publishDate | 2017-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Forum of Clinical Oncology |
| spelling | doaj.art-4f3bc5cc852a4b62ae652c42167541a52022-12-22T00:44:43ZengSciendoForum of Clinical Oncology1792-362X2017-06-0181152110.1515/fco-2015-0025fco-2015-0025Developing an algorithm for the management of Renal Cell Carcinoma: focus on metastatic diseaseKyriazoglou Anastasios0Dimitriadis Ioannis1Bamias Aristotelis2General Hospital Alexandra, Athens, GreeceGeneral Hospital Alexandra, Athens, GreeceGeneral Hospital Alexandra, Athens, GreeceThe treatment paradigm in renal cell carcinoma (RCC) is rapidly changing. The incidental finding of small renal tumours combined with the development of novel therapeutic agents targeting the vascular endothelial growth factor (VEGF) or the mammalian target of rapamycin (mTOR) pathways or inhibiting the interaction of the programmed death 1 (PD 1) receptor with its ligand have dramatically improved the prognosis of patients suffering from this malignancy. At the same time, the availability of multiple effective options with similar indications complicates the development and applicability of guidelines in this disease. We conducted a systematic review of the existing guidelines. Our study revealed areas of agreement as well as of discrepancies amongst the published scientific papers included. By critically evaluating these areas, we developed a therapeutic algorithm for RCC. We suggest that this methodology can define the practices of wide applicability and areas of future research.https://doi.org/10.1515/fco-2015-0025renal cell carcinomametastatic diseasetherapeutic algorithm |
| spellingShingle | Kyriazoglou Anastasios Dimitriadis Ioannis Bamias Aristotelis Developing an algorithm for the management of Renal Cell Carcinoma: focus on metastatic disease Forum of Clinical Oncology renal cell carcinoma metastatic disease therapeutic algorithm |
| title | Developing an algorithm for the management of Renal Cell Carcinoma: focus on metastatic disease |
| title_full | Developing an algorithm for the management of Renal Cell Carcinoma: focus on metastatic disease |
| title_fullStr | Developing an algorithm for the management of Renal Cell Carcinoma: focus on metastatic disease |
| title_full_unstemmed | Developing an algorithm for the management of Renal Cell Carcinoma: focus on metastatic disease |
| title_short | Developing an algorithm for the management of Renal Cell Carcinoma: focus on metastatic disease |
| title_sort | developing an algorithm for the management of renal cell carcinoma focus on metastatic disease |
| topic | renal cell carcinoma metastatic disease therapeutic algorithm |
| url | https://doi.org/10.1515/fco-2015-0025 |
| work_keys_str_mv | AT kyriazoglouanastasios developinganalgorithmforthemanagementofrenalcellcarcinomafocusonmetastaticdisease AT dimitriadisioannis developinganalgorithmforthemanagementofrenalcellcarcinomafocusonmetastaticdisease AT bamiasaristotelis developinganalgorithmforthemanagementofrenalcellcarcinomafocusonmetastaticdisease |