Inhibiting mir-34a-5p regulates doxorubicin-induced autophagy disorder and alleviates myocardial pyroptosis by targeting Sirt3-AMPK pathway

Inhibiting mir-34a-5p regulates doxorubicin-induced autophagy disorder and alleviates myocardial pyroptosis by targeting Sirt3-AMPK pathway

Doxorubicin (DOX) is a commonly used chemotherapy drug widely applied in various cancers such as breast cancer, leukemia, and sarcomas. However, its usage is limited by cardiotoxicity. Additionally, the cardiac toxicity of DOX accumulates with dose and duration, making it imperative to identify ther...

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Bibliographic Details
Main Authors: Zuoquan Zhong, Yefei Gao, Jiedong Zhou, Fang Wang, Peipei Zhang, Songqing Hu, Haowei Wu, Haifei Lou, Jufang Chi, Hui Lin, Hangyuan Guo
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Mir-34a-5p
Sirt3
Doxorubicin-induced cardiotoxicity
Autophagy
Pyroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222301452X

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