Gut Microbiome Signature Are Correlated With Bone Mineral Density Alterations in the Chinese Elders
ObjectiveOsteoporosis (OP), clinically featured with a low bone mineral density (BMD) and high risk of bone fracture, has become a major risk factor of disability and death in the elders, especially in postmenopausal women. The gut microbiome (GM) is thought to be implicated in bone metabolism. Here...
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| Format: | Article |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.827575/full |
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| author | Yangyang Wang Xiaoguang Gao Jing Lv Yuhong Zeng Qingmei Li Liping Wang Yuanyuan Zhang Wenjie Gao Jihan Wang |
| author_facet | Yangyang Wang Xiaoguang Gao Jing Lv Yuhong Zeng Qingmei Li Liping Wang Yuanyuan Zhang Wenjie Gao Jihan Wang |
| author_sort | Yangyang Wang |
| collection | DOAJ |
| description | ObjectiveOsteoporosis (OP), clinically featured with a low bone mineral density (BMD) and high risk of bone fracture, has become a major risk factor of disability and death in the elders, especially in postmenopausal women. The gut microbiome (GM) is thought to be implicated in bone metabolism. Herein, we clarified the composition signature and gene functional profile of GM in older people with normal and low BMD.Design and MethodsA total of 455 participants underwent the BMD measurement and biochemical detection. GM analysis was further performed on 113 cases of postmenopausal women and men aged over 50, including both 16S rRNA and metagenomic sequencing.ResultsGenerally, the BMD value was significantly lower in the older age groups, especially in the postmenopausal women. Consistently, we observed obvious vitamin D deficiency or insufficiency in females (compared to the male, P < 0.0001). The results from 16S rRNA sequencing revealed higher numbers of OTUs and diversity indexes in females than in males. The abundance in composition of Firmicutes and Clostridiales were correlated with the BMD values in females. LEfSe analysis discovered several enriched bacteria taxons in OP and normal control (NC) subgroups. A positive correlation between the number of genes and BMD values was observed in females based on metagenomic sequencing analysis. Furthermore, we identified the connecting modules among the GM composition – gene functional signature – BMD value/T score in both females and males.ConclusionsThis study provides evidences upon which to understand the mechanisms of the effects of GM on bone health, consequently revealing the physiology status and potential diagnostic/therapeutic targets based on GM for OP and postmenopausal osteoporosis (PMOP). Besides, the status of vitamin D deficiency or insufficiency need to be concerned and improved in the Chinese people. |
| first_indexed | 2024-12-13T01:12:44Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-13T01:12:44Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-4f3e69ba43f542c0917a549dbbf08ab22022-12-22T00:04:25ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-03-011210.3389/fcimb.2022.827575827575Gut Microbiome Signature Are Correlated With Bone Mineral Density Alterations in the Chinese EldersYangyang Wang0Xiaoguang Gao1Jing Lv2Yuhong Zeng3Qingmei Li4Liping Wang5Yuanyuan Zhang6Wenjie Gao7Jihan Wang8School of Electronics and Information, Northwestern Polytechnical University, Xi’an, ChinaSchool of Electronics and Information, Northwestern Polytechnical University, Xi’an, ChinaClinical Laboratory of Honghui Hospital, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Osteoporosis, Honghui Hospital, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Osteoporosis, Honghui Hospital, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Cardiology, Honghui Hospital, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Cardiology, Honghui Hospital, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Spine Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaXi’an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, Xi’an, ChinaObjectiveOsteoporosis (OP), clinically featured with a low bone mineral density (BMD) and high risk of bone fracture, has become a major risk factor of disability and death in the elders, especially in postmenopausal women. The gut microbiome (GM) is thought to be implicated in bone metabolism. Herein, we clarified the composition signature and gene functional profile of GM in older people with normal and low BMD.Design and MethodsA total of 455 participants underwent the BMD measurement and biochemical detection. GM analysis was further performed on 113 cases of postmenopausal women and men aged over 50, including both 16S rRNA and metagenomic sequencing.ResultsGenerally, the BMD value was significantly lower in the older age groups, especially in the postmenopausal women. Consistently, we observed obvious vitamin D deficiency or insufficiency in females (compared to the male, P < 0.0001). The results from 16S rRNA sequencing revealed higher numbers of OTUs and diversity indexes in females than in males. The abundance in composition of Firmicutes and Clostridiales were correlated with the BMD values in females. LEfSe analysis discovered several enriched bacteria taxons in OP and normal control (NC) subgroups. A positive correlation between the number of genes and BMD values was observed in females based on metagenomic sequencing analysis. Furthermore, we identified the connecting modules among the GM composition – gene functional signature – BMD value/T score in both females and males.ConclusionsThis study provides evidences upon which to understand the mechanisms of the effects of GM on bone health, consequently revealing the physiology status and potential diagnostic/therapeutic targets based on GM for OP and postmenopausal osteoporosis (PMOP). Besides, the status of vitamin D deficiency or insufficiency need to be concerned and improved in the Chinese people.https://www.frontiersin.org/articles/10.3389/fcimb.2022.827575/fullosteoporosispostmenopausal osteoporosisbone mineral densitygut microbiomemetagenomics |
| spellingShingle | Yangyang Wang Xiaoguang Gao Jing Lv Yuhong Zeng Qingmei Li Liping Wang Yuanyuan Zhang Wenjie Gao Jihan Wang Gut Microbiome Signature Are Correlated With Bone Mineral Density Alterations in the Chinese Elders Frontiers in Cellular and Infection Microbiology osteoporosis postmenopausal osteoporosis bone mineral density gut microbiome metagenomics |
| title | Gut Microbiome Signature Are Correlated With Bone Mineral Density Alterations in the Chinese Elders |
| title_full | Gut Microbiome Signature Are Correlated With Bone Mineral Density Alterations in the Chinese Elders |
| title_fullStr | Gut Microbiome Signature Are Correlated With Bone Mineral Density Alterations in the Chinese Elders |
| title_full_unstemmed | Gut Microbiome Signature Are Correlated With Bone Mineral Density Alterations in the Chinese Elders |
| title_short | Gut Microbiome Signature Are Correlated With Bone Mineral Density Alterations in the Chinese Elders |
| title_sort | gut microbiome signature are correlated with bone mineral density alterations in the chinese elders |
| topic | osteoporosis postmenopausal osteoporosis bone mineral density gut microbiome metagenomics |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.827575/full |
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