Immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial function
IntroductionThe immune systems of both the mother and the newborn face significant challenges during birth. Proper immune regulation after birth is essential for the survival of neonates. Numerous studies have demonstrated that the neonatal immune system is relatively immature, particularly in its a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368624/full |
| _version_ | 1797244766292803584 |
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| author | Eliška Miková Viktor Černý Olga Novotná Petra Petrásková Kristýna Boráková Zdenek Hel Jiří Hrdý |
| author_facet | Eliška Miková Viktor Černý Olga Novotná Petra Petrásková Kristýna Boráková Zdenek Hel Jiří Hrdý |
| author_sort | Eliška Miková |
| collection | DOAJ |
| description | IntroductionThe immune systems of both the mother and the newborn face significant challenges during birth. Proper immune regulation after birth is essential for the survival of neonates. Numerous studies have demonstrated that the neonatal immune system is relatively immature, particularly in its adaptive arm, placing the primary responsibility for immune surveillance on innate immunity.MethodsGiven the significant role of neutrophils in protecting the neonate after birth, we conducted a study investigating the properties of neutrophils in newborn cord blood using various methodological approaches.ResultsOur findings demonstrate the presence of immature low-density neutrophils in the cord blood, which are likely responsible for the observed elevated expression of genes coding for proteins essential to antimicrobial response, including myeloperoxidase, neutrophils elastase, and defensins.DiscussionWe propose that these cells function normally and support the protection of newborns early after birth. Furthermore, our results suggest that the mode of delivery might significantly influence the programming of neutrophil function. The presented findings emphasize the importance of distinct neutrophil subpopulations in neonatal immunity and their potential impact on early postnatal health. |
| first_indexed | 2024-04-24T19:16:13Z |
| format | Article |
| id | doaj.art-4f426c433caf4f06b3a93f6c91a9492e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T19:16:13Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4f426c433caf4f06b3a93f6c91a9492e2024-03-26T04:59:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-03-011510.3389/fimmu.2024.13686241368624Immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial functionEliška Miková0Viktor Černý1Olga Novotná2Petra Petrásková3Kristýna Boráková4Zdenek Hel5Jiří Hrdý6Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University, Prague, CzechiaInstitute of Immunology and Microbiology, First Faculty of Medicine, Charles University, Prague, CzechiaInstitute of Immunology and Microbiology, First Faculty of Medicine, Charles University, Prague, CzechiaInstitute of Immunology and Microbiology, First Faculty of Medicine, Charles University, Prague, CzechiaDepartment of Neonatology, Institute for the Care of Mother and Child, Prague, CzechiaPathology Department, University of Alabama at Birmingham, Birmingham, AL, United StatesInstitute of Immunology and Microbiology, First Faculty of Medicine, Charles University, Prague, CzechiaIntroductionThe immune systems of both the mother and the newborn face significant challenges during birth. Proper immune regulation after birth is essential for the survival of neonates. Numerous studies have demonstrated that the neonatal immune system is relatively immature, particularly in its adaptive arm, placing the primary responsibility for immune surveillance on innate immunity.MethodsGiven the significant role of neutrophils in protecting the neonate after birth, we conducted a study investigating the properties of neutrophils in newborn cord blood using various methodological approaches.ResultsOur findings demonstrate the presence of immature low-density neutrophils in the cord blood, which are likely responsible for the observed elevated expression of genes coding for proteins essential to antimicrobial response, including myeloperoxidase, neutrophils elastase, and defensins.DiscussionWe propose that these cells function normally and support the protection of newborns early after birth. Furthermore, our results suggest that the mode of delivery might significantly influence the programming of neutrophil function. The presented findings emphasize the importance of distinct neutrophil subpopulations in neonatal immunity and their potential impact on early postnatal health.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368624/fullneutrophilscord bloodmyeloperoxidasedefensinsoxidative burst |
| spellingShingle | Eliška Miková Viktor Černý Olga Novotná Petra Petrásková Kristýna Boráková Zdenek Hel Jiří Hrdý Immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial function Frontiers in Immunology neutrophils cord blood myeloperoxidase defensins oxidative burst |
| title | Immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial function |
| title_full | Immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial function |
| title_fullStr | Immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial function |
| title_full_unstemmed | Immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial function |
| title_short | Immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial function |
| title_sort | immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial function |
| topic | neutrophils cord blood myeloperoxidase defensins oxidative burst |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368624/full |
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