Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment
Bronchiolitis obliterans (BO) is the most remarkable pulmonary sequels of war-related sulfur mustard inhalation. There is little if any data about long-term efficacy of associated BO treatment. Five years spirometric records of three groups of patients with obstructive pulmonary diseases (asthma, CO...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2016-10-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/5193 |
| _version_ | 1818644108722307072 |
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| author | Hamidreza Abtahi Soheil Peiman Morteza Foroumandi Enayat Safavi |
| author_facet | Hamidreza Abtahi Soheil Peiman Morteza Foroumandi Enayat Safavi |
| author_sort | Hamidreza Abtahi |
| collection | DOAJ |
| description | Bronchiolitis obliterans (BO) is the most remarkable pulmonary sequels of war-related sulfur mustard inhalation. There is little if any data about long-term efficacy of associated BO treatment. Five years spirometric records of three groups of patients with obstructive pulmonary diseases (asthma, COPD, BO) and documented sulfur mustard inhalation were evaluated. The BO patients were treated with inhaled Seretide 125-250/25 (2 puffs BID), azithromycin (250 mg, three times/week) and N-acetylcysteine (1200-1800/day). Asthma and COPD patients were treated according to existing guidelines. Seventy-three (38 asthma, 16 COPD and 19 BO) patients completed the 5 years follow-up. Basal and final FEV1 in BO patients (2.69±0.81 and 2.39±0.65 respectively) were not significantly different from COPD patients (2.46±0.56 and 1.96±0.76 respectively). There was also no significant difference between the yearly FEV1 decline in BO patients compared to COPD patients (60±84 cc vs. 99±79 cc respectively, P=0.163). The non-significant difference of FEV1 decline in BO compared to COPD patients suggests the effectiveness of azithromycin, inhaled steroid and N-acetyl cysteine in BO patients. Considering safety and possible effectiveness, this treatment is recommended until more data is available from controlled clinical studies. |
| first_indexed | 2024-12-17T00:09:37Z |
| format | Article |
| id | doaj.art-4f42ee39f3b9433ebd8d07033ff8b171 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-17T00:09:37Z |
| publishDate | 2016-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-4f42ee39f3b9433ebd8d07033ff8b1712022-12-21T22:10:51ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942016-10-015495047Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans TreatmentHamidreza Abtahi0Soheil Peiman1Morteza Foroumandi2Enayat Safavi3Department of Pulmonary and Critical Care, Advanced Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND department of Pulmonary and Critical Care, Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Pulmonary and Critical Care, Advanced Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran.AND Department of Internal Medicine, Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Internal Medicine, Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Pulmonary and Critical Care, Advanced Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Pulmonary and Critical Care, Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Bronchiolitis obliterans (BO) is the most remarkable pulmonary sequels of war-related sulfur mustard inhalation. There is little if any data about long-term efficacy of associated BO treatment. Five years spirometric records of three groups of patients with obstructive pulmonary diseases (asthma, COPD, BO) and documented sulfur mustard inhalation were evaluated. The BO patients were treated with inhaled Seretide 125-250/25 (2 puffs BID), azithromycin (250 mg, three times/week) and N-acetylcysteine (1200-1800/day). Asthma and COPD patients were treated according to existing guidelines. Seventy-three (38 asthma, 16 COPD and 19 BO) patients completed the 5 years follow-up. Basal and final FEV1 in BO patients (2.69±0.81 and 2.39±0.65 respectively) were not significantly different from COPD patients (2.46±0.56 and 1.96±0.76 respectively). There was also no significant difference between the yearly FEV1 decline in BO patients compared to COPD patients (60±84 cc vs. 99±79 cc respectively, P=0.163). The non-significant difference of FEV1 decline in BO compared to COPD patients suggests the effectiveness of azithromycin, inhaled steroid and N-acetyl cysteine in BO patients. Considering safety and possible effectiveness, this treatment is recommended until more data is available from controlled clinical studies.https://acta.tums.ac.ir/index.php/acta/article/view/5193BioterrorismBronchiolitisSulfur mustardMacrolideTreatment |
| spellingShingle | Hamidreza Abtahi Soheil Peiman Morteza Foroumandi Enayat Safavi Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment Acta Medica Iranica Bioterrorism Bronchiolitis Sulfur mustard Macrolide Treatment |
| title | Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment |
| title_full | Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment |
| title_fullStr | Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment |
| title_full_unstemmed | Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment |
| title_short | Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment |
| title_sort | long term follow up of sulfur mustard related bronchiolitis obliterans treatment |
| topic | Bioterrorism Bronchiolitis Sulfur mustard Macrolide Treatment |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/5193 |
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