Photoactive and Luminescent Transition Metal Complexes as Anticancer Agents: A Guiding Light in the Search for New and Improved Cancer Treatments
Cancer continues to be responsible for the deaths of more than 9 million people worldwide each year. Current treatment options are diverse, but low success rates, particularly for those with late-stage cancers, continue to be a problem for clinicians and their patients. The effort by researchers glo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/3/578 |
| _version_ | 1797472755092815872 |
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| author | Brondwyn S. McGhie Janice R. Aldrich-Wright |
| author_facet | Brondwyn S. McGhie Janice R. Aldrich-Wright |
| author_sort | Brondwyn S. McGhie |
| collection | DOAJ |
| description | Cancer continues to be responsible for the deaths of more than 9 million people worldwide each year. Current treatment options are diverse, but low success rates, particularly for those with late-stage cancers, continue to be a problem for clinicians and their patients. The effort by researchers globally to find alternative treatment options is ongoing. In the present study, we focused on innovations in inorganic anticancer therapies, specifically those with photoactive and luminescent properties. Transition metals offer distinct advantages compared to wholly organic compounds in both chemotherapeutics and luminescence properties. Here we report on the characteristics that result from discrete structural changes that have been expertly used to fine-tune their properties, and how diverse inherent luminescent properties have been widely employed to monitor cellular localization to photodynamic therapy. |
| first_indexed | 2024-03-09T20:05:43Z |
| format | Article |
| id | doaj.art-4f43217ae0e745218bc61b5b41a50673 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:05:43Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-4f43217ae0e745218bc61b5b41a506732023-11-24T00:32:17ZengMDPI AGBiomedicines2227-90592022-03-0110357810.3390/biomedicines10030578Photoactive and Luminescent Transition Metal Complexes as Anticancer Agents: A Guiding Light in the Search for New and Improved Cancer TreatmentsBrondwyn S. McGhie0Janice R. Aldrich-Wright1Nanoscale Organisation and Dynamics Group, School of Science, Western Sydney University, Locked Bag 1797 Penrith South DC, Sydney, NSW 2751, AustraliaNanoscale Organisation and Dynamics Group, School of Science, Western Sydney University, Locked Bag 1797 Penrith South DC, Sydney, NSW 2751, AustraliaCancer continues to be responsible for the deaths of more than 9 million people worldwide each year. Current treatment options are diverse, but low success rates, particularly for those with late-stage cancers, continue to be a problem for clinicians and their patients. The effort by researchers globally to find alternative treatment options is ongoing. In the present study, we focused on innovations in inorganic anticancer therapies, specifically those with photoactive and luminescent properties. Transition metals offer distinct advantages compared to wholly organic compounds in both chemotherapeutics and luminescence properties. Here we report on the characteristics that result from discrete structural changes that have been expertly used to fine-tune their properties, and how diverse inherent luminescent properties have been widely employed to monitor cellular localization to photodynamic therapy.https://www.mdpi.com/2227-9059/10/3/578cancerluminescentchemotherapeuticsmetaliridiumruthenium |
| spellingShingle | Brondwyn S. McGhie Janice R. Aldrich-Wright Photoactive and Luminescent Transition Metal Complexes as Anticancer Agents: A Guiding Light in the Search for New and Improved Cancer Treatments Biomedicines cancer luminescent chemotherapeutics metal iridium ruthenium |
| title | Photoactive and Luminescent Transition Metal Complexes as Anticancer Agents: A Guiding Light in the Search for New and Improved Cancer Treatments |
| title_full | Photoactive and Luminescent Transition Metal Complexes as Anticancer Agents: A Guiding Light in the Search for New and Improved Cancer Treatments |
| title_fullStr | Photoactive and Luminescent Transition Metal Complexes as Anticancer Agents: A Guiding Light in the Search for New and Improved Cancer Treatments |
| title_full_unstemmed | Photoactive and Luminescent Transition Metal Complexes as Anticancer Agents: A Guiding Light in the Search for New and Improved Cancer Treatments |
| title_short | Photoactive and Luminescent Transition Metal Complexes as Anticancer Agents: A Guiding Light in the Search for New and Improved Cancer Treatments |
| title_sort | photoactive and luminescent transition metal complexes as anticancer agents a guiding light in the search for new and improved cancer treatments |
| topic | cancer luminescent chemotherapeutics metal iridium ruthenium |
| url | https://www.mdpi.com/2227-9059/10/3/578 |
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