Notch Signaling in HSC Emergence: When, Why and How
The hematopoietic stem cell (HSC) sustains blood homeostasis throughout life in vertebrates. During embryonic development, HSCs emerge from the aorta-gonads and mesonephros (AGM) region along with hematopoietic progenitors within hematopoietic clusters which are found in the dorsal aorta, the main a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/3/358 |
| _version_ | 1827661203101450240 |
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| author | Roshana Thambyrajah Anna Bigas |
| author_facet | Roshana Thambyrajah Anna Bigas |
| author_sort | Roshana Thambyrajah |
| collection | DOAJ |
| description | The hematopoietic stem cell (HSC) sustains blood homeostasis throughout life in vertebrates. During embryonic development, HSCs emerge from the aorta-gonads and mesonephros (AGM) region along with hematopoietic progenitors within hematopoietic clusters which are found in the dorsal aorta, the main arterial vessel. Notch signaling, which is essential for arterial specification of the aorta, is also crucial in hematopoietic development and HSC activity. In this review, we will present and discuss the evidence that we have for Notch activity in hematopoietic cell fate specification and the crosstalk with the endothelial and arterial lineage. The core hematopoietic program is conserved across vertebrates and here we review studies conducted using different models of vertebrate hematopoiesis, including zebrafish, mouse and in vitro differentiated Embryonic stem cells. To fulfill the goal of engineering HSCs in vitro, we need to understand the molecular processes that modulate Notch signaling during HSC emergence in a temporal and spatial context. Here, we review relevant contributions from different model systems that are required to specify precursors of HSC and HSC activity through Notch interactions at different stages of development. |
| first_indexed | 2024-03-10T00:04:12Z |
| format | Article |
| id | doaj.art-4f43515fbcb74e4a9b6b5bddbdebcd26 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:04:12Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4f43515fbcb74e4a9b6b5bddbdebcd262023-11-23T16:10:30ZengMDPI AGCells2073-44092022-01-0111335810.3390/cells11030358Notch Signaling in HSC Emergence: When, Why and HowRoshana Thambyrajah0Anna Bigas1Program in Cancer Research, Institut Hospital del Mar d’Investigacions Mèdiques, CIBERONC, 08003 Barcelona, SpainProgram in Cancer Research, Institut Hospital del Mar d’Investigacions Mèdiques, CIBERONC, 08003 Barcelona, SpainThe hematopoietic stem cell (HSC) sustains blood homeostasis throughout life in vertebrates. During embryonic development, HSCs emerge from the aorta-gonads and mesonephros (AGM) region along with hematopoietic progenitors within hematopoietic clusters which are found in the dorsal aorta, the main arterial vessel. Notch signaling, which is essential for arterial specification of the aorta, is also crucial in hematopoietic development and HSC activity. In this review, we will present and discuss the evidence that we have for Notch activity in hematopoietic cell fate specification and the crosstalk with the endothelial and arterial lineage. The core hematopoietic program is conserved across vertebrates and here we review studies conducted using different models of vertebrate hematopoiesis, including zebrafish, mouse and in vitro differentiated Embryonic stem cells. To fulfill the goal of engineering HSCs in vitro, we need to understand the molecular processes that modulate Notch signaling during HSC emergence in a temporal and spatial context. Here, we review relevant contributions from different model systems that are required to specify precursors of HSC and HSC activity through Notch interactions at different stages of development.https://www.mdpi.com/2073-4409/11/3/358Notch signalingHSCdevelopmental hematopoiesisAGM |
| spellingShingle | Roshana Thambyrajah Anna Bigas Notch Signaling in HSC Emergence: When, Why and How Cells Notch signaling HSC developmental hematopoiesis AGM |
| title | Notch Signaling in HSC Emergence: When, Why and How |
| title_full | Notch Signaling in HSC Emergence: When, Why and How |
| title_fullStr | Notch Signaling in HSC Emergence: When, Why and How |
| title_full_unstemmed | Notch Signaling in HSC Emergence: When, Why and How |
| title_short | Notch Signaling in HSC Emergence: When, Why and How |
| title_sort | notch signaling in hsc emergence when why and how |
| topic | Notch signaling HSC developmental hematopoiesis AGM |
| url | https://www.mdpi.com/2073-4409/11/3/358 |
| work_keys_str_mv | AT roshanathambyrajah notchsignalinginhscemergencewhenwhyandhow AT annabigas notchsignalinginhscemergencewhenwhyandhow |