Sex Differences in Quality of Life in Patients with Ischemia with No Obstructive Coronary Artery Disease (INOCA): A Patient Self-Report Retrospective Survey from INOCA International
Women with obstructive coronary artery disease (CAD) have a relatively lower quality of life (QoL) compared to men, but our understanding of sex differences in QoL in ischemia with no obstructive coronary artery disease (INOCA) is limited. We conducted a survey of patient members of INOCA Internatio...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/17/5646 |
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| author | Sachini Ranasinghe C. Noel Bairey Merz Najah Khan Janet Wei Maria George Colin Berry Alaide Chieffo Paolo G. Camici Filippo Crea Juan Carlos Kaski Mario Marzilli Martha Gulati |
| author_facet | Sachini Ranasinghe C. Noel Bairey Merz Najah Khan Janet Wei Maria George Colin Berry Alaide Chieffo Paolo G. Camici Filippo Crea Juan Carlos Kaski Mario Marzilli Martha Gulati |
| author_sort | Sachini Ranasinghe |
| collection | DOAJ |
| description | Women with obstructive coronary artery disease (CAD) have a relatively lower quality of life (QoL) compared to men, but our understanding of sex differences in QoL in ischemia with no obstructive coronary artery disease (INOCA) is limited. We conducted a survey of patient members of INOCA International with an assessment of self-reported health measures. Functional capacity was retrospectively estimated using the Duke Activity Status Index (DASI), assessing levels of activities performed before and after INOCA symptom onset. Of the 1579 patient members, the overall survey completion rate was 21%. Women represented 91% of the respondents. Estimated functional capacity, expressed as metabolic equivalents (METs), was higher before compared to after INOCA diagnosis comparably for both women and men. For every one MET decline in functional capacity, there was a significantly greater decline in QoL for men compared with women in physical health (4.0 ± 1.1 vs. 2.9 ± 0.3 days/month, <i>p</i> < 0.001), mental health (2.4 ± 1.2 vs. 1.8 ± 0.3 days/month, <i>p</i> = 0.001), and social health/recreational activities (4.1 ± 1.0 vs. 2.9 ± 0.3 days/month, <i>p</i> = 0.0001), respectively. In an international survey of patients living with INOCA, despite similar diagnoses, clinical comorbidities, and symptoms, INOCA-related functional capacity declines are associated with a greater adverse impact on QoL in men compared to women. |
| first_indexed | 2024-03-10T23:19:23Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T23:19:23Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4f44da264b3c4f7387db2c37762869ab2023-11-19T08:23:28ZengMDPI AGJournal of Clinical Medicine2077-03832023-08-011217564610.3390/jcm12175646Sex Differences in Quality of Life in Patients with Ischemia with No Obstructive Coronary Artery Disease (INOCA): A Patient Self-Report Retrospective Survey from INOCA InternationalSachini Ranasinghe0C. Noel Bairey Merz1Najah Khan2Janet Wei3Maria George4Colin Berry5Alaide Chieffo6Paolo G. Camici7Filippo Crea8Juan Carlos Kaski9Mario Marzilli10Martha Gulati11Barbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USABarbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAHouston Methodist Hospital, Houston, TX 77030, USABarbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAINOCA International, Glasgow G12 8QQ, UKBritish Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8QQ, UKIRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyIRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyDepartment of Cardiology, Catholic University of the Sacred Heart, 00168 Rome, ItalyMolecular and Clinical Sciences Research Institute, St. George’s University of London, London SW17 0RE, UKDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine-Cardiology Division, University of Pisa, 56126 Pisa, ItalyBarbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAWomen with obstructive coronary artery disease (CAD) have a relatively lower quality of life (QoL) compared to men, but our understanding of sex differences in QoL in ischemia with no obstructive coronary artery disease (INOCA) is limited. We conducted a survey of patient members of INOCA International with an assessment of self-reported health measures. Functional capacity was retrospectively estimated using the Duke Activity Status Index (DASI), assessing levels of activities performed before and after INOCA symptom onset. Of the 1579 patient members, the overall survey completion rate was 21%. Women represented 91% of the respondents. Estimated functional capacity, expressed as metabolic equivalents (METs), was higher before compared to after INOCA diagnosis comparably for both women and men. For every one MET decline in functional capacity, there was a significantly greater decline in QoL for men compared with women in physical health (4.0 ± 1.1 vs. 2.9 ± 0.3 days/month, <i>p</i> < 0.001), mental health (2.4 ± 1.2 vs. 1.8 ± 0.3 days/month, <i>p</i> = 0.001), and social health/recreational activities (4.1 ± 1.0 vs. 2.9 ± 0.3 days/month, <i>p</i> = 0.0001), respectively. In an international survey of patients living with INOCA, despite similar diagnoses, clinical comorbidities, and symptoms, INOCA-related functional capacity declines are associated with a greater adverse impact on QoL in men compared to women.https://www.mdpi.com/2077-0383/12/17/5646ischemia with no obstructive coronary artery disease (INOCA)ischemic heart diseasesex differencesquality of lifefunctional capacity |
| spellingShingle | Sachini Ranasinghe C. Noel Bairey Merz Najah Khan Janet Wei Maria George Colin Berry Alaide Chieffo Paolo G. Camici Filippo Crea Juan Carlos Kaski Mario Marzilli Martha Gulati Sex Differences in Quality of Life in Patients with Ischemia with No Obstructive Coronary Artery Disease (INOCA): A Patient Self-Report Retrospective Survey from INOCA International Journal of Clinical Medicine ischemia with no obstructive coronary artery disease (INOCA) ischemic heart disease sex differences quality of life functional capacity |
| title | Sex Differences in Quality of Life in Patients with Ischemia with No Obstructive Coronary Artery Disease (INOCA): A Patient Self-Report Retrospective Survey from INOCA International |
| title_full | Sex Differences in Quality of Life in Patients with Ischemia with No Obstructive Coronary Artery Disease (INOCA): A Patient Self-Report Retrospective Survey from INOCA International |
| title_fullStr | Sex Differences in Quality of Life in Patients with Ischemia with No Obstructive Coronary Artery Disease (INOCA): A Patient Self-Report Retrospective Survey from INOCA International |
| title_full_unstemmed | Sex Differences in Quality of Life in Patients with Ischemia with No Obstructive Coronary Artery Disease (INOCA): A Patient Self-Report Retrospective Survey from INOCA International |
| title_short | Sex Differences in Quality of Life in Patients with Ischemia with No Obstructive Coronary Artery Disease (INOCA): A Patient Self-Report Retrospective Survey from INOCA International |
| title_sort | sex differences in quality of life in patients with ischemia with no obstructive coronary artery disease inoca a patient self report retrospective survey from inoca international |
| topic | ischemia with no obstructive coronary artery disease (INOCA) ischemic heart disease sex differences quality of life functional capacity |
| url | https://www.mdpi.com/2077-0383/12/17/5646 |
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